Alcoholism Treatment Is Potentially Effective against COVID-19
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. One of them is used to treat alcohol addiction, and the other is for cancer.
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Scientists Devise Cheaper and Easier Method for Synthesising Layered Rare Earth Hydroxides—'Chemical Sandwiches’
Researchers at HSE University and the RAS Kurnakov Institute of General and Inorganic Chemistry have developed a simplified and cost-effective method for synthesising layered rare earth hydroxides using propylene oxide. This reagent helps streamline the process and reduce its duration by several hours. In the future, this method is expected to facilitate the synthesis of various hydroxide-based hybrid materials, including photocatalysts for water purification and luminescent materials for solid-phase thermometers. The paper has been published in the Russian Journal of Inorganic Chemistry.
‘Digital Chemistry Is the Cutting Edge of Science’
In 2024, a new track ‘Digital Chemistry and Artificial Intelligence Technologies’ will open within the Bachelor’s programme in Chemistry. This track will offer courses in digital engineering, multi-scale modelling, chemometrics, and chemoinformatics, as well as big data and artificial intelligence technologies. Specialists from HSE University, Zelinsky Institute of Organic Chemistry, Moscow Institute of Physics and Technology, and Peter the Great St Petersburg Polytechnic University will be among the lecturers.
Chemists Improve Membranes for Water Treatment and Desalination
Chemists at HSE University, Kurnakov Institute of General and Inorganic Chemistry, and the University of Science and Technology of China have developed membranes with enhanced properties. The researchers experimentally revealed the impact of various factors on the desalination process and on the selectivity of ion separation. According to the study authors, their research will enable a more precise prediction of the properties of new ion-exchange membranes used in water treatment and desalination. The study findings have been published in Desalination.
HSE Biologists Explain Mechanism behind Coronavirus Evolution
A team of researchers, including scientists of the HSE Faculty of Biology and Biotechnology, have analysed the evolutionary path of the coronavirus from the Wuhan variant to Omicron. Their findings indicate that many genomic mutations in SARS-CoV-2 are shaped by processes occurring in the intestines and lungs, where the virus acquires the ability to evade the inhibitory effects of microRNA molecules. The study findings have been published in the Journal of Medical Virology.
‘The Main Thing Is to Try to Learn New Things by Any Honest Means’
Chemist Polina Yurova works in the same laboratory of the IGIC RAS that she first visited as a tenth grader. In this interview with the Young Scientists of HSE University project, she spoke about the creation of ion-exchange membranes, the ‘hair’ of black holes and her favourite Moscow park.
Russian Scientists Present New Application for Nanophotonic Sensor
A joint research team from HSE, Skoltech, MPGU and MISIS has developed a compact sensor for biochemical analysis, opening up a new frontier in the development of the ‘lab-on-a-chip’. Using bovine serum albumin film as an example, the researchers proved that the chip surface can be adapted for selective analysis of multicomponent solutions. Along with enabling accurate blood tests with only 3 to 5 microliters of blood, the chip will help doctors to detect specific disease markers. The study was published in Analytical Chemistry.
Russian Researchers Explain Origins of Dangerous Coronavirus Variants
HSE researchers, in collaboration with their colleagues from Skoltech and the Central Research Institute for Epidemiology, have uncovered the mechanisms behind the emergence of new and dangerous coronavirus variants, such as Alpha, Delta, Omicron, and others. They have discovered that the likelihood of a substitution occurring at a specific site of the SARS-CoV-2 genome is dependent on concordant substitutions occurring at other sites. This explains why new and more contagious variants of the virus can emerge unexpectedly and differ significantly from those that were previously circulating. The study’s findings have been published in eLife.
Scientists Create Uniquely Stable Trimeric Model of Coronavirus Spike Transmembrane Domain
A team of Russian scientists, including HSE MIEM researchers, have presented a 3D model of SARS-CoV-2 S-protein transmembrane (TM) domain. Previously, the TM domain had only been believed to anchor the S-protein in its viral membrane without being involved in rearrangement and fusion with the host cell. Yet according to recent studies, the TM domain appears to have a function in the transmission of genetic information, but its role is not yet fully understood. The researchers believe that the model they have created can contribute to a better understanding of viral mechanisms and potentially lead to the development of novel antiviral drugs. The study has been published in the International Journal of Molecular Sciences.
Fluoride Additive to Boost Production of Sedatives
Russian researchers from HSE University and the Russian Academy of Sciences Nesmeyanov Institute of Organoelement Compounds have come up with a new method of enhancing the chemical reaction involved in producing gamma-aminobutyric acid (GABA) analogues used in sedative drugs. Adding fluoride to the catalyst more than doubled the yield of the pure product and increased the total reaction yield by 2.5 times. This approach is expected to make the production of certain drug components more efficient and less costly. The study has been published in the Journal of Organic Chemistry.
HSE University Launches New Master’s Programme in Chemistry
In 2023, the first Master's programme 'Chemistry of Molecular Systems and Materials' at the HSE Faculty of Chemistry will enrol students. Half of the study time will be devoted to research projects in the field of modern fundamental and applied research on the topics studied at five institutes of the Russian Academy of Sciences. Dmitrii Roitershtein, Academic Supervisor of the programme and Associate Professor at the Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry, spoke about the programme to the HSE News Service.