• A
  • A
  • A
  • ABC
  • ABC
  • ABC
  • А
  • А
  • А
  • А
  • А
Regular version of the site

Student
Title
Supervisor
Faculty
Educational Programme
Final Grade
Year of Graduation
Igor Karpikov
Experimental Designs Based on Weighted Differential Entropies in Clinical Trials
2018
The problem of finding "the best" among a number of alternatives is one of the main in Statistics. In clinical trials this can be stated in the form of the question: which arm is the most efficacious for a certain disease treatment? Clinical trials is a procedure that allows to answer this question with a certain degree of confidence.

Consider a set of p alternative arms {A1,...,Ap}, and n patients {x1,...,xn} (experimental sample). Experimental design in clinical trials is an algorithm that governs allocation of an arm from the set {A1,...,Ap} to each patient {x1,...,xn}. Performance of experimental design is measured by a set of criteria which depends on the Phase of clinical trials and other details of the experiment.

In this thesis, based on the ideas of recent researches, author derives a number of new experimental designs which utilize information gain principle. The proposed designs are compared to currently widespread alternatives in a comprehensive simulation study.

Student Theses at HSE must be completed in accordance with the University Rules and regulations specified by each educational programme.

Summaries of all theses must be published and made freely available on the HSE website.

The full text of a thesis can be published in open access on the HSE website only if the authoring student (copyright holder) agrees, or, if the thesis was written by a team of students, if all the co-authors (copyright holders) agree. After a thesis is published on the HSE website, it obtains the status of an online publication.

Student theses are objects of copyright and their use is subject to limitations in accordance with the Russian Federation’s law on intellectual property.

In the event that a thesis is quoted or otherwise used, reference to the author’s name and the source of quotation is required.

Search all student theses