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Cortical Mapping of Proximal Muscles in Children with Amyoplasia Using MEG

Student: Zagranichnova Darya

Supervisor: Anna Shestakova

Faculty: Institute for Cognitive Neuroscience

Educational Programme: Cognitive Sciences and Technologies: From Neuron to Cognition (Master)

Year of Graduation: 2019

In this study we use MEG to map the cortical activation of proximal muscles and demonstrate its feasibility to further help with the diagnosis of children with amioplasia. In particular, we aim to use several analyses to reveal the potential of MEG to further diagnose patients with arthrogryposis. This may be able to provide critical clinical information to surgeons and explore further interventions such as stimulation or prosthetics for improving quality of life in research that is beyond the scope of this thesis. The surgery outcome depends not only on the characteristics of the target muscle, but the plastic changes occurring in the central neural system after transplantation. In the previous studies it was shown, that the distance of the cortical representations (such as upper limb- v.s. –lower limb) may be of importance for the outcome of muscles reinnervation interventions. However, there is no information for tendon-muscular rearrangements and especially for closely located muscles of the upper limb and shoulder girdle. We assumed that research on the somatotopic organization of the proximal upper limb muscles would lead to better understanding of the process of motor system reorganization after such intervention and even can give additional clues for clinicians choosing the most optimal muscle to transplant and/or improve post-surgery rehabilitation. We propose that MEG can be used to estimate cortical involvement in the motor control of proximal muscles in the context of neuroplastic changes as a result of changes at the peripheral level. This study is intended to develop and test the MEG study protocols to probe somatotopy of the proximal muscles, e.g bicep brachii, to determine the ratio of the cortical representations of different muscles during their isometric contraction and electrical stimulation.

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