Coevolution of Transcriptional Factors with Heat Shock Proteins in Bacteria

Student: Medvedeva Kseniia

Educational Programme: Data Analysis for Biology and Medicine (Master)

Final Grade: 9

Year of Graduation: 2019

In this work regulons of MerR family transcriptional factor HspR are reconstructed using comparative genomic approach. Based on relative positions of paired binding sites a putative mechanism of transcriptional repression of regulated operons by HspR is suggested. In this case HspR is possibly in complex with DnaK chaperone. Co-ocurence in bacterial genomes and relative positions of genes encoding transcriptional factors HspR and HrcA and chaperons DnaK and GroeL respectively is analyzed. Predictions are made about taxonomic occurrence of physical interactions of these transcriptional factors and chaperons.

Full text (added May 22, 2019)

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