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Modeling of Predisposition of Cardio-Vascular Diseases in Different Ethnic Groups of Russia Based on Genetic Portraits

Student: Dina Sayfutdinova

Supervisor: Maria Poptsova

Faculty: Faculty of Computer Science

Educational Programme: Applied Mathematics and Information Science (Bachelor)

Year of Graduation: 2020

Pathologies of the cardiovascular system are the most common causes of death. One of the medical approaches to the treatment of such diseases is pharmacogenetics. In this paper, data containing the results of genotyping of patients from various ethnic groups in Russia were analyzed using data analysis methods to identify significant differences between these groups. The warfarin dosing was also computed for each ethnic group using an International Warfarin Pharmacogenetics Consortium Algorithm. The results of this study may broaden the knowledge about the similarity of patients from different ethnic groups in Russia by their genetic portrait, as well as their reaction to warfarin. keywords: ethnic group, allele frequency, warfarin, pharmacogenomics, single-nucleotide polymorphism

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