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Regular version of the site

Neuroplasticity of language: reorganization of neuronal activity in brain damage



In this project, we aimed to capture the mechanisms of neuroplasticity following damage to language areas of the cortex and examine how they are modified by an intensive language therapy.

We designed and tested an fMRI paradigm for action naming in groups of healthy volunteers and persons with aphasia. In the first group we observed normative activation for Russian verb retrieval located primarily in the inferior frontal gyrus. Next, we have collected fMRI and behavioral data of 45 individuals with aphasia with varying severity of naming deficits and lesion localization in the left hemisphere. We established that significant impairments in naming ability are produced by massive lesions in the left inferior frontal region. Further, milder impairments are observed if there is activation in the perilesional regions and more severe if the activation is not present or is present in the right hemisphere.


We also adapted the “Verb Network Strengthening Treatment” (Edmonds, Nadeau, & Kiran, 2009; Edmonds, 2014) for Russian clinical practice. In this particular therapy protocol each verb through the generation of its arguments activates various semantic networks, this in turn facilitates its retrieval and retrieval of other verbs, not trained but connected semantically to the trained one. We have demonstrated the effectiveness of this protocol in groups of patients with different aphasia types. We have also gathered unique neuroimaging data demonstrating functional reorganization of activation in language regions following therapy.


Overall, these data support the critical role of left inferior frontal cortex regions in naming - in particular, during action naming. If the region is heavily impaired, neural reorganization is no longer effective. If the lesion is located elsewhere, productive neural reorganization is possible and involves perifocal regions in the left hemisphere and homological regions in the right hemisphere.

Intensive speech therapy enables effective reorganization of the neural substrate of the naming function. It facilitates activation in the inferior frontal cortex regions in both right and left hemispheres. Observed patterns of behavioral change and neural reorganization suggest the effectiveness of this intensive therapy and confirm that the language function can be reorganized on the neural level even in chronic patients.

Publications

 

Купцова С.В., Власова Р.М., Драгой О.В., Иванова М.В., Малютина С.А., Петрушевский Г.А., Федина О.Н., Гутырчик  Е.Ф. (2015). Особенности реорганизации речевых зон мозга у больных с разными формами афазии. // Вестник ВГУ. Серия: Лингвистика и межкультурная коммуникация. - № 4 , 74-81.
Власова Р.М., Драгой О.В., Иванова М.В., Козинцева Е.Г., Малютина С.А., Петрушевский Г.А., Федина О.Н., Гутырчик  Е.Ф. (2015). фМРТ исследование реорганизации речевого субстрата при афазии .// Одиннадцатый международный междисциплинарный конгресс «Нейронаука для медицины и психологии» (стр. 110–111). Судак, Крым.
Драгой О.В., Власова Р.М., Козинцева Е.Г., Малютина С.А., Акинина Ю.С., Петрушевский А.В., Федина О.Н., Гутырчик Е.Ф., Иванова М.В. (2015). фМРТ-исследование называния действий при афазии.  //В кн.: Когнитивная наука в Москве: новые исследования. Материалы конференции (16 июня 2015 г.) / Науч. ред.: Е. В. Печенкова, М. В. Фаликман. М.: OOO «Буки Веди», 2015. С. 119-124.
Kozintseva, E.G., Dragoy, O.V., Ivanova, M.V., Malyutina, S.A., Akinina, Yu.S., Sevan, D.A., Kuptsova, S.V., Petrushevsky, A.G., Fedina, O.N., & Gutyrchik, E.F. (2014). An fMRI study of naming actions in aphasia: the role of right hemisphere activation. Proceedings of the Sixth International Conference on Cognitive Science. Kaliningrad, Russia, 64-65.
Kozintseva, E.G., Dragoy, O.V., Malyutina, S.A., Ivanova, M.V., Sevan, D.A., Kuptsova, S.V., Petrushevsky, A.G., Fedina, O.N., & Gutyrchik, E.F. (2013). Naming actions in non-fluent aphasia: an fMRI study of compensatory reorganization of brain activity. Stem-, Spraak- en Taalpathologie, 18 (S01), 98-99.
Козинцева Е.Г., Драгой О.В., Малютина С.А., Иванова М.В., Севан Д.А., Купцова С.В., Петрушевский А.В.,  Федина О.Н., Гутырчик Е.Ф. (2013). Называние действий пациентами с афазией: компенсаторная реорганизация активности мозга. //В кн.: Когнитивная наука в Москве: новые исследования. Тезисы конференции (19 июня 2013 г.) / Науч. ред.: Е. В. Печенкова, М. В. Фаликман. М.: [б.и.], 2013. С. 149-153.


Conference talks

Ivanova, M., Dragoy, O., Vlasova, R., Kozintseva, E., Akinina, Yu., Malyutina, S., Petrushevsky, A., Fedina, O., & Gutyrchik, E. (2014, August). Neural circuitries underlying distinct naming errors in aphasia.  Poster presented at the Sixth Annual Meeting of the Society for the Neurobiology of Language, Amsterdam, Netherlands.

Dragoy, O., Ivanova, M., Malyutina, S., Kozintseva, E., Akinina, Yu., Sevan, D.,  Kuptsova S., Petrushevsky, A., Fedina, O., & Gutyrchik, E. (2013, November).  Right brain, wrong verb: functional neuroanatomy of action naming in aphasia.  Poster presented at the Fifth Annual Meeting of the Society for the Neurobiology of Language, San Diego, CA, USA.

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The research is supported by RFFI grant №13-06-00651а 92013 - 2015), principal investigator - Maria Ivanova


 

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