Scientists Create Uniquely Stable Trimeric Model of Coronavirus Spike Transmembrane Domain
A team of Russian scientists, including HSE MIEM researchers, have presented a 3D model of SARS-CoV-2 S-protein transmembrane (TM) domain. Previously, the TM domain had only been believed to anchor the S-protein in its viral membrane without being involved in rearrangement and fusion with the host cell. Yet according to recent studies, the TM domain appears to have a function in the transmission of genetic information, but its role is not yet fully understood. The researchers believe that the model they have created can contribute to a better understanding of viral mechanisms and potentially lead to the development of novel antiviral drugs. The study has been published in the International Journal of Molecular Sciences.
Russian Scientists Present New Application for Nanophotonic Sensor
A joint research team from HSE, Skoltech, MPGU and MISIS has developed a compact sensor for biochemical analysis, opening up a new frontier in the development of the ‘lab-on-a-chip’. Using bovine serum albumin film as an example, the researchers proved that the chip surface can be adapted for selective analysis of multicomponent solutions. Along with enabling accurate blood tests with only 3 to 5 microliters of blood, the chip will help doctors to detect specific disease markers. The study was published in Analytical Chemistry.
Fluoride Additive to Boost Production of Sedatives
Russian researchers from HSE University and the Russian Academy of Sciences Nesmeyanov Institute of Organoelement Compounds have come up with a new method of enhancing the chemical reaction involved in producing gamma-aminobutyric acid (GABA) analogues used in sedative drugs. Adding fluoride to the catalyst more than doubled the yield of the pure product and increased the total reaction yield by 2.5 times. This approach is expected to make the production of certain drug components more efficient and less costly. The study has been published in the Journal of Organic Chemistry.
HSE University Launches New Master’s Programme in Chemistry
In 2023, the first Master's programme 'Chemistry of Molecular Systems and Materials' at the HSE Faculty of Chemistry will enrol students. Half of the study time will be devoted to research projects in the field of modern fundamental and applied research on the topics studied at five institutes of the Russian Academy of Sciences. Dmitrii Roitershtein, Academic Supervisor of the programme and Associate Professor at the Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry, spoke about the programme to the HSE News Service.
Russian Chemists Improve Seawater Desalination Membrane
A team of researchers of the HSE Faculty of Chemistry Joint Department of Inorganic Chemistry and Materials Science with the RAS Kurnakov Institute of General and Inorganic Chemistry have designed a novel type of hybrid ion-exchange membrane. Such membranes can be used to produce drinking water from seawater, which is particularly relevant for areas with access to the sea and a shortage of drinking water. The study is published in Desalination.
‘We Want to Share Our Research with the Whole World’
The HSE University Faculty of Chemistry opened three years ago, and its first intake of undergraduate students is set to graduate in 2023. These students have already demonstrated impressive results in their research—half of second and third-year students have publications in journals indexed in WoS and Scopus, almost a third of which are in Q1 journals. Andrey Yaroslavtsev, Head of the Chemistry programme and Academic of the Russian Academy of Sciences (RAS), told the HSE University News Service about the secret of this success.
New Data Gained on Double Perovskite Oxides
The Journal of Alloys and Compounds has published an article coauthored by the Institute of Solid State Chemistry and Mechanochemistry (the Ural Branch of the Russian Academy of Sciences), the Donostia International Physics Centre, and the HSE Tikhonov Moscow Institute of Electronics and Mathematics on the characteristics of cubic double perovskite oxides. To date, experimental measurements of the minerals’ characteristics have not corresponded to the results of theoretical modelling. The work marks the first time that researchers have set themselves the task of explaining this disparity. The data obtained will allow researchers to improve low-temperature fuel cell technologies—one of the main alternatives to current sources of electricity.
Wonderful Lanthanides: Researchers Systematize Global Data on the Properties of Rare-Earth Metals
Yury Belousov, Associate Professor at the HSE Faculty of Chemistry, joined his colleagues from Moscow State University, Lebedev Physical Institute, and the University of Camerino, Italy, to work on a review, in which they compared and analysed over 200 lanthanide azolecarboxylates. The scholars were the first to systematize the scattered published information in a single source, which will be useful for technology developments in electronics, metallurgy and nuclear medicine, as well as in the chemical and nuclear industries. The review was published in Coordination Chemistry Reviews.
RAS Institute of Problems of Chemical Physics Launches Joint Department with HSE Faculty of Chemistry
The new Department will prepare students for careers in cutting edge research and engineering, as well as entrepreneurial and commercial development. They will be able to promote their own innovative projects and projects developed by their colleagues. The Department is headed by Professor Sergey Aldoshin, full member of Russian Academy of Sciences.
HSE Faculty of Chemistry Scientists Discover New Anti-cancer Molecule
A group of Moscow scientists has discovered and explained the activity mechanism of a new anti-cancer molecule — diphenylisoxazole. This molecule has been shown to be effective against human cancer cells. The research, published in the journal Bioorganic & Medicinal Chemistry Letters, makes it possible to produce an affordable cancer treatment drug.
Alcoholism Treatment Is Potentially Effective against COVID-19
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. One of them is used to treat alcohol addiction, and the other is for cancer.