Stepan Nersisyan
- Junior Research Fellow:Faculty of Biology and Biotechnology / International Laboratory of Microphysiological Systems
- Lecturer, Doctoral Student:Faculty of Biology and Biotechnology / Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Stepan Nersisyan has been at HSE University since 2020.
Postgraduate Studies
1st year of study
Approved topic of thesis: Topic of Thesis not yet confirmed
Academic Supervisor: Tonevitsky, Alexander
Courses (2021/2022)
- Bioinformatics (Bachelor’s programme; Faculty of Biology and Biotechnology; 2 year, 3, 4 module)Rus
- Systems Biology and Bioinformatics (Master’s programme; Faculty of Biology and Biotechnology; 1 year, 3, 4 module)Rus
- Past Courses
Publications28
- Article Nersisyan S., Zhiyanov A., Shkurnikov M., Tonevitsky A. T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations // Nucleic Acids Research. 2022. Vol. 50. No. D1. P. D883-D887. doi
- Article Shkurnikov M., Nersisyan S., Tatjana J., Galatenko A. V., Ivan G., Valery V., Tonevitsky A. Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19 // Frontiers in Immunology. 2021. Vol. 12. Article 641900. doi
- Article Nersisyan S., Novosad V., Engibaryan N., Ushkaryov Y., Nikulin S., Tonevitsky A. ECM–Receptor Regulatory Network and Its Prognostic Role in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 782699. doi
- Article Nikulin S., Zakharova G., Poloznikov A., Raigorodskaya M., Wicklein D., Schumacher U., Nersisyan S., Bergquist J., Bakalkin G., Astakhova L., Tonevitsky A. Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells // Frontiers in Genetics. 2021. Vol. 12. Article 662843. doi
- Article Knyazev E., Nersisyan S., Tonevitsky A. Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue Barriers // Frontiers in Immunology. 2021. Vol. 12. Article 636966. doi
- Article Nersisyan S., Maltseva D., Tonevitsky A. Fra-2 Overexpression Upregulates Pro-metastatic Cell-adhesion Molecules, Promotes Pulmonary Metastasis and Reduces Survival in a Spontaneous // Journal of Cancer Research and Clinical Oncology. 2021. P. 1-18. doi (in press)
- Article Poloznikov A., Nersisyan S., Hushpulian D., Kazakov E., Tonevitsky A., Kazakov S., Vechorko V., Nikulin S., Makarova J., Gazaryan I. G. HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons // Frontiers in Pharmacology. 2021. Vol. 11. Article 621054. doi
- Article Zhiyanov A., Nersisyan S., Tonevitsky A. Hairpin sequence and structure is associated with features of isomiR biogenesis // RNA Biology. 2021. Vol. 18. No. sup1. P. 430-438. doi
- Article Nersisyan S., Galatenko A. V., Chekova M., Tonevitsky A. Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 662468. doi
- Article Nersisyan S., Galatenko A. V., Maltseva D., Raigorodskaya M., Makarova J., Tonevitsky A. Low expression of CD24 is associated with poor survival in colorectal cancer // Biochimie. 2021. P. 1-11. doi (in press)
- Article Nersisyan S., Galatenko A. V., Galatenko V. V., Shkurnikov M., Tonevitsky A. miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence // Plos One. 2021. Vol. 16. No. 4. Article e0249424. doi
- Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
- Article Shkurnikov M. Yu., Nersisyan S. A., Osepyan A. S., Maltseva D. V., Knyazev E. N. Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 208-210. doi
- Article S. A. Nersisyan, M. Yu. Shkurnikov, E. N. Knyazev. Factors Involved in miRNA Processing Change Its Expression Level during Imitation of Hypoxia in BeWo b30 Cells // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 205-207. doi
- Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
- Article Nersisyan S., Engibaryan N., Gorbonos A., Kirdey K., Makhonin A., Tonevitsky A. Potential role of cellular miRNAs in coronavirus-host interplay // PeerJ. 2020. Vol. 8. Article e9994. doi
- Article Мальцева Д. В., Шкурников М. Ю., Нерсисян С. А., Никулин С. В., Курносов А. А., Райгородская М. П., Осипьянц А. И., Тоневицкий Е. А. Гипоксия усиливает трансцитоз в энтероцитах кишечника // Вестник Российского государственного медицинского университета. 2020. № 4. С. 62-69. doi
- Article Нерсисян С. А., Шкурников М. Ю., Осипьянц А. И., Вечорко В. И. Роль регуляции генов AПФ2/TMPRSS2 изоформами микроРНК кишечника в патогенезе COVID-19 // Вестник Российского государственного медицинского университета. 2020. № 2. С. 17-20. doi
- Chapter Galatenko A. V., Nersisyan S., Pankratieva V. Clustering of Biomedical Data Using the Greedy Clustering Algorithm Based on Interval Pattern Concepts, in: Proceedings of the International Workshop "What can FCA do for Artificial Intelligence?" (FCA4AI at IJCAI/ECAI 2019). , 2019. P. 65-74.
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Zaidi S., Baranova A., Schumacher U., Wicklein D., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 122. P. 1-7. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
- Article Galatenko A. V., Nersisyan S., Zhuk D. NP-hardness of the problem of optimal box positioning // Mathematics. 2019. Vol. 7. No. 8. P. 711. doi
- Article Pfaller C., Donohue R., Nersisyan S., Brodsky L., Cattaneo R. Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1 p150 // PLoS Biology. 2018. Vol. 16. P. 1-36. doi
- Article Nersisyan S., Staroverov V. Gradient estimation for hexagonal grids and its application to classification of instrumentally registered tactile images // WSEAS Transactions on Applied and Theoretical Mechanics. 2018. Vol. 13. P. 123-129.
- Article Alexandrov D., Nersisyan S. Identification of Contact Angle and Heterogenity Detection in Tactile Images // International Journal of Biology and Biomedical Engineering. 2018. Vol. 12. P. 186-191.
- Book Александров Д. Е., Галатенко А. В., Галатенко В. В., Нерсисян С. А., Подольский В. Е., Соколов М. Э., Солодова Р. Ф., Староверов В. М. О методах обработки и автоматизированного анализа инструментальных тактильных образов. ООО «Макс Пресс», 2018. doi
- Article Nersisyan S., Pankratieva V., Staroverov V., Podolskii V. A Greedy Clustering Algorithm Based on Interval Pattern Concepts and the Problem of Optimal Box Positioning // Journal of Applied Mathematics. 2017. Vol. 2017. P. 1-9. doi
- Article Nersisyan S., Rakhmatulin Y. Pattern recognition in low-resolution instrumental tactile imaging // International Journal of Circuits, Systems and Signal Processing. 2017. Vol. 11. P. 306-313.
Members of the International Laboratory of Microphysiological Systems and the Laboratory of Molecular Physiology participated in RECOMB 2021
25th International Conference on Research in Computational Molecular Biology (RECOMB 2021) was held online on August 29th - September 2nd. Staff of the Faculty of Biology and Biotechnology - Stepan Nersisyan, Alexey Galatenko, Diana Maltseva and Alexander Tonevitsky participated in a poster session with the report «miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence»
Russian Scientists Investigate the Immune Response to SARS-CoV-2 Variants
HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.
HSE Researchers Discover Nucleotide Sequence Responsible for Effectively Fighting Pathologies
Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors). The discovery will help predict errors in microRNA behaviour and create drugs that can detect targets (such as viruses) more effectively. The results of the study have been published in the RNA Biology journal.
HSE University and Business Russia to Establish Bioeconomy Advisory Board
The decision to establish the Advisory Board was made during a meeting between the Investment Club of Business Russia (‘Delovaya Rossiya’, an all-Russia public organization), and the HSE University Faculty of Biology and Biotechnology, which launched a new Master’s Programme in Bioeconomics last year. The Advisory Board will include leading researchers, entrepreneurs, and investors working in the fields of biotechnology, environmental studies, and sustainable development. Sergey Nedoroslev, Business Russia Co-Chair, and Alexander Tonevitsky, Dean of the Faculty of Biology and Biotechnology at HSE University, will also serve as board members.
The member of the International Laboratory of Microphysiological Systems presented his research at the seminar of the Armenian Institute of Bioinformatics
Stepan Nersisyan, Junior Research Fellow of the International Laboratory of Microphysiological Systems, made a presentation at the seminar of the Armenian Institute of Bioinformatics.
Researchers Establish Intracellular Interaction Network in Breast Cancer
HSE University researchers have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE.
Researchers Reveal Genetic Predisposition to Severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.
International Laboratory of Microphysiological Systems at the conference 2020 - International Conference on Research inLife-Sciences & Healthcare (ICRLSH)
On December 11-12, 2020, employees of the International Laboratory of Microphysiological Systems made a presentation at the conference 2020 – International Conference on Research in Life-Sciences & Healthcare (ICRLSH), London, UK
Members of the International Laboratory of Microphysiological Systems and students of the Faculty of Biology and Biotechnology gave an interview to the correspondent of “MIR” TV company on the results of their study of molecules capable to suppress the replication of coronaviruses
Faculty of Biology and Biotechnology researchers in their interview to the correspondent of «MIR» TV company talked about their study on interactions between microRNA molecules and human coronaviruses.
Researchers Find Therapeutic Targets to Fight SARS-CoV-2
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.