Stepan Nersisyan
- Junior Research Fellow:International Laboratory of Microphysiological Systems
- Lecturer:Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Stepan Nersisyan has been at HSE University since 2020.
Publications17
- Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
- Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
- Article Nersisyan S., Engibaryan N., Gorbonos A., Kirdey K., Makhonin A., Tonevitsky A. Potential role of cellular miRNAs in coronavirus-host interplay // PeerJ. 2020. Vol. 8. No. e9994. P. 1-16. doi
- Article Мальцева Д. В., Шкурников М. Ю., Нерсисян С. А., Никулин С. В., Курносов А. А., Райгородская М. П., Осипьянц А. И., Тоневицкий Е. А. Гипоксия усиливает трансцитоз в энтероцитах кишечника // Вестник Российского государственного медицинского университета. 2020. № 4. С. 62-69. doi
- Article Шкурников М. Ю., Нерсисян С. А., Осепян А. Ш., Князев Е. Н. РАЗЛИЧИЯ В РАБОТЕ ФЕРМЕНТОВ DROSHA И DICER В ОБРАЗЦАХ КОЛОРЕКТАЛЬНОГО РАКА И НОРМАЛЬНОЙ ТКАНИ ТОЛСТОЙ КИШКИ // Доклады Академии Наук. Биохимия и биофизика. 2020. Т. 493. № 1. С. 400-403. doi
- Article Нерсисян С. А., Шкурников М. Ю., Осипьянц А. И., Вечорко В. И. Роль регуляции генов AПФ2/TMPRSS2 изоформами микроРНК кишечника в патогенезе COVID-19 // Вестник Российского государственного медицинского университета. 2020. № 2. С. 17-20. doi
- Article Нерсисян С. А., Шкурников М. Ю., Князев Е. Н. ФАКТОРЫ, УЧАСТВУЮЩИЕ В СОЗРЕВАНИИ МИКРОРНК, ИЗМЕНЯЮТ УРОВЕНЬ СВОЕЙ ЭКСПРЕССИИ ПРИ ИМИТАЦИИ ГИПОКСИИ ПЛАЦЕНТЫ В КЛЕТКАХ BeWo b30 // Доклады Академии Наук. Науки о жизни (Российская Федерация). 2020. Т. 493. № 1. С. 385-388. doi
- Chapter Galatenko A. V., Nersisyan S., Pankratieva V. Clustering of Biomedical Data Using the Greedy Clustering Algorithm Based on Interval Pattern Concepts, in: Proceedings of the International Workshop "What can FCA do for Artificial Intelligence?" (FCA4AI at IJCAI/ECAI 2019). , 2019. P. 65-74.
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Zaidi S., Baranova A., Schumacher U., Wicklein D., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 122. P. 1-7. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
- Article Galatenko A. V., Nersisyan S., Zhuk D. NP-hardness of the problem of optimal box positioning // Mathematics. 2019. Vol. 7. No. 8. P. 711. doi
- Article Pfaller C., Donohue R., Nersisyan S., Brodsky L., Cattaneo R. Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1 p150 // PLoS Biology. 2018. Vol. 16. P. 1-36. doi
- Article Nersisyan S., Staroverov V. Gradient estimation for hexagonal grids and its application to classification of instrumentally registered tactile images // WSEAS Transactions on Applied and Theoretical Mechanics. 2018. Vol. 13. P. 123-129.
- Article Alexandrov D., Nersisyan S. Identification of Contact Angle and Heterogenity Detection in Tactile Images // International Journal of Biology and Biomedical Engineering. 2018. Vol. 12. P. 186-191.
- Book Александров Д. Е., Галатенко А. В., Галатенко В. В., Нерсисян С. А., Подольский В. Е., Соколов М. Э., Солодова Р. Ф., Староверов В. М. О методах обработки и автоматизированного анализа инструментальных тактильных образов. ООО «Макс Пресс», 2018. doi
- Article Nersisyan S., Pankratieva V., Staroverov V., Podolskii V. A Greedy Clustering Algorithm Based on Interval Pattern Concepts and the Problem of Optimal Box Positioning // Journal of Applied Mathematics. 2017. Vol. 2017. P. 1-9. doi
- Article Nersisyan S., Rakhmatulin Y. Pattern recognition in low-resolution instrumental tactile imaging // International Journal of Circuits, Systems and Signal Processing. 2017. Vol. 11. P. 306-313.
International Laboratory of Microphysiological Systems at the conference 2020 - International Conference on Research inLife-Sciences & Healthcare (ICRLSH)
On December 11-12, 2020, employees of the International Laboratory of Microphysiological Systems made a presentation at the conference 2020 – International Conference on Research in Life-Sciences & Healthcare (ICRLSH), London, UK
Members of the International Laboratory of Microphysiological Systems and students of the Faculty of Biology and Biotechnology gave an interview to the correspondent of “MIR” TV company on the results of their study of molecules capable to suppress the replication of coronaviruses
Faculty of Biology and Biotechnology researchers in their interview to the correspondent of «MIR» TV company talked about their study on interactions between microRNA molecules and human coronaviruses.
Researchers Find Therapeutic Targets to Fight SARS-CoV-2
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.
