The aim of our center is to investigate mechanisms of the decision making and cognitive control, perception and generation of speech, perception of the multimodal information by active and passive brain decoding using technologies of dynamical neurovizualization, connectivity assessment, computational modeling and neurointerfaces.Our methods include navigated Transcranial Magnetic Stimulation (nTMS), Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS), Magnetoencephalography (MEG), Electroencephalography (EEG), Eyetracking, functional and structural magnetic resonance imaging (fMRI, MRI).
Research base: National Research University Higher School of Economics unique equipment “Automated system for non-invasive brain stimulation allows synchronous registration of neural oscillations and tracking of eye-movements fixation”. It includes 2 TMS stimulators: MagPro X100 (MagVenture) with Localite navigation system which uses structural MRI scans for precise localization of the stimulation points, 2 Eye-trackers: SMI REDm and Eyelink 1000 plus, 128-channel BRAINAMP DC amplifier for EEG (Brain Products), TES System. Following equipment was also used: Vectorview MEG-system from Elekta Neuromag (MGPPU), 3-T MRI scanner Siemens (FSBNU NTSN).
Results: We have conducted a wide range of the interdisciplinary research studies, aimed at deepening our knowledge about fundamental mechanisms of the brain functioning, namely, the interaction between different neurocognitive systems, as well as between different levels of the information processing of speech perception, decision making, performing movements and other activities, including resting state.
The results about automatic lexical assessment in visual modality by eyetracker were reported (Pokhoday M. et al., PloS one, 13(4), e0195547). Research on the role of attention in visual task involving linguistic processing was performed combining EEG research of spatial mapping of the number and time concepts. In addition a research on the role of judgments about the memorization of words in horizontal space was performed. The multimodal study of the interactions of attention and syntactic choice in Russian and English languages was published (Novitskiy, et al., «Bilingualism: Language and Cognition, 2018. Pp. 1-19). We studied sounds’ perception during the third stage of sleep using evoked potentials in response to the global and local irregularities of the sound sequences. We also probed neuronal mechanisms of speech recovery in patients’ undergoing intensive speech therapy and tDCS of the speech areas. MEG studies included the investigation of the dynamics of the evoked mismatch negativity responses in patients with post-stroke aphasia undergoing intensive speech neurorehabilitation. We also conducted a number of other experiments dedicated to probing of the relationships between cognitive control, verbal communication and perception. The study of the cross-domain structural priming between mathematical and linguistic processes was conducted. The study of linguistic relativity in the effects of displacement of the visual field in case of the naming and memorization of colors was performed. An fMRI study of the exploitation resources was also conducted. We continued our series of studies on the neurobiological mechanisms of social influence, in particular, in the context of punishment by a third person, were provided (Zinchenko O. O., Arsalidou M. “Brain responses to social norms: Meta-analyses of fMRI studies” // Human Brain Mapping. 2018. Vol. 39. No. 2. P. 955-970.). Moreover, we continued our research of cognitive dissonance using EEG and tDCS techniques. The research on the stability of the cortical representations of the distal muscles using nTMS was continued as well. A model of the thalamocortical dynamics during spontaneous neuronal activity was developed. The TMS technique was used to study the interaction between the brain mirror system neurons and the processes of the sensorimotor learning.
The degree of the research implementation, recommendations for its implementation and the results of the research implementation: We have achieved significant results in the field of the applied research, which paves the way for the new technologies and practical recommendations. Significant results were obtained in the development of the neurocognitive technologies, for example, we created an algorithm for the automatic detection of interconnected spikes and a new method for detecting functional relationships with a null-phase shift in MEG and EEG data (Ossadtchi et al., 2018, Neuroimage). The new quantitative approaches for the assessment of TMS-cortical representations were developed (Novikov et al.,,Software for Quantitative Analysis of TMS Mapping Results” // Front. Hum. Neurosci. 2018. 12:239). New protocols for patients neurorehabilitation were developed as well (stroke patients, patients with arthrogryposis). New algorithms relating to the partitioning of the movement trajectories into sub-components (for increasing the efficiency of the exoskeleton) were created.