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Active and Passive Decoding of the Neural Processes During Cognitive Perfoemance and Neuroeconomic Tasks Execution

Priority areas of development: humanitarian
2018
The project has been carried out as part of the HSE Program of Fundamental Studies.

The aim of our center is to investigate mechanisms of the decision making and cognitive control, perception and generation of speech, perception of the multimodal information by active and passive brain decoding using technologies of dynamical neurovizualization, connectivity assessment, computational modeling and neurointerfaces.Our methods include navigated Transcranial Magnetic Stimulation (nTMS), Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS), Magnetoencephalography (MEG), Electroencephalography (EEG), Eyetracking, functional and structural magnetic resonance imaging (fMRI, MRI).

Research base: National Research University Higher School of Economics unique equipment “Automated system for non-invasive brain stimulation allows synchronous registration of neural oscillations and tracking of eye-movements fixation”. It includes 2 TMS stimulators: MagPro X100 (MagVenture) with Localite navigation system which uses structural MRI scans for precise localization of the stimulation points, 2 Eye-trackers: SMI REDm and Eyelink 1000 plus, 128-channel BRAINAMP DC amplifier for EEG (Brain Products), TES System. Following equipment was also used: Vectorview MEG-system from Elekta Neuromag (MGPPU), 3-T MRI scanner Siemens (FSBNU NTSN).

Results: We have conducted a wide range of the interdisciplinary research studies, aimed at deepening our knowledge about fundamental mechanisms of the brain functioning, namely, the interaction between different neurocognitive systems, as well as between different levels of the information processing of speech perception, decision making, performing movements and other activities, including resting state.

The results about automatic lexical assessment in visual modality by eyetracker were reported (Pokhoday M. et al., PloS one, 13(4), e0195547). Research on the role of attention in visual task involving linguistic processing was performed combining EEG research of spatial mapping of the number and time concepts. In addition a research on the role of judgments about the memorization of words in horizontal space was performed. The multimodal study of the interactions of attention and syntactic choice in Russian and English languages was published (Novitskiy, et al., «Bilingualism: Language and Cognition, 2018. Pp. 1-19). We studied sounds’ perception during the third stage of sleep using evoked potentials in response to the global and local irregularities of the sound sequences. We also probed neuronal mechanisms of speech recovery in patients’ undergoing intensive speech therapy and tDCS of the speech areas. MEG studies included the investigation of the dynamics of the evoked mismatch negativity responses in patients with post-stroke aphasia undergoing intensive speech neurorehabilitation. We also conducted a number of other experiments dedicated to probing of the relationships between cognitive control, verbal communication and perception. The study of the cross-domain structural priming between mathematical and linguistic processes was conducted. The study of linguistic relativity in the effects of displacement of the visual field in case of the naming and memorization of colors was performed. An fMRI study of the exploitation resources was also conducted. We continued our series of studies on the neurobiological mechanisms of social influence, in particular, in the context of punishment by a third person, were provided (Zinchenko O. O., Arsalidou M. “Brain responses to social norms: Meta-analyses of fMRI studies” // Human Brain Mapping. 2018. Vol. 39. No. 2. P. 955-970.).  Moreover, we continued our research of cognitive dissonance using EEG and tDCS techniques. The research on the stability of the cortical representations of the distal muscles using nTMS was continued as well. A model of the thalamocortical dynamics during spontaneous neuronal activity was developed. The TMS technique was used to study the interaction between the brain mirror system neurons and the processes of the sensorimotor learning.

The degree of the research implementation, recommendations for its implementation and the results of the research implementation: We have achieved significant results in the field of the applied research, which paves the way for the new technologies and practical recommendations. Significant results were obtained in the development of the neurocognitive technologies, for example, we created an algorithm for the automatic detection of interconnected spikes and a new method for detecting functional relationships with a null-phase shift in MEG and EEG data (Ossadtchi et al., 2018, Neuroimage). The new quantitative approaches for the assessment of TMS-cortical representations were developed (Novikov et al.,,Software for Quantitative Analysis of TMS Mapping Results” // Front. Hum. Neurosci. 2018. 12:239). New protocols for patients neurorehabilitation were developed as well (stroke patients, patients with arthrogryposis). New algorithms relating to the partitioning of the movement trajectories into sub-components (for increasing the efficiency of the exoskeleton) were created.

Publications:


Moiseeva V., Nazarova M., Novikov P., Иванина Е. О., Kozlova K., Nikulin V. Stability of cortical muscle representations: TMS motor mapping test-retest study, in: 2018 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2018. Online.. San Diego : Society for Neuroscience, 2018. P. 1-2.
Pavel A. Novikov, Maria A. Nazarova, Vadim V. Nikulin. TMSmap – software for quantitative analysis of TMS mapping results // Frontiers in Human Neuroscience. 2018. Vol. 12. No. 239. P. 1-12. doi
Благовещенский Е. Д., Агранович О. Е., Кононова Е. Л., Назарова М. А., Баиндурашвили А. Г., Шестакова А. Н., Габбасова Е. Л., Никулин В. В. Особенности электрофизиологической активности коры больших полушарий мозга у детей с артрогрипозом // Нервно-мышечные болезни. 2018. Т. 8. № 2. С. 25-32. doi
Martín-Luengo B., Luna K. Judgments of learning in horizontal space // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. No. 2. P. 201-208. doi
Karlos L., Martín-Luengo B., Albuquerque P. B. Do delayed judgements of learning reduce metamemory illusions? A meta-analysis // The Quarterly Journal of Experimental Psychology. 2018. No. 7. P. 1626-1636. doi
Zakharov D., Gutkin B., Krupa M., Kuznetsov A. High-frequency forced oscillations in neuronlike elements // Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2018. Vol. 97. No. 6. P. 062211-1-062211-5. doi
Novikov P., Arsalidou M. CoordsFinder - software tool for systematic search for brain coordinates of interest for area-based meta-analyses, in: 2018 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2018. Online.. San Diego : Society for Neuroscience, 2018. P. 1-2.
Luna K., Albuquerque P. B., Martín-Luengo B. Cognitive load eliminates the effect of perceptual information on judgments of learning with sentences // Memory and Cognition. 2019. Vol. 47. No. 1. P. 106-116. doi
Gutkin B., di Volo M., Morozova E., Kuznetsov A., Lapish C. Dynamical ventral tegmental area circuit mechanisms of alcohol‐dependent dopamine release // European Journal of Neuroscience. 2018 doi
Iemi L., Busch N. A. Moment-to-moment fluctuations in neuronal excitability bias subjective perception rather than decision-making / Cold Spring Harbor Laboratory. Series New Results "BioRxiv". 2017. doi
Zinchenko O. O., Arsalidou M. Brain responses to social norms: Meta-analyses of fMRI studies // Human Brain Mapping. 2018. Vol. 39. No. 2. P. 955-970. doi
Buchin A., Kerr C., Huberfeld G., Miles R., Gutkin B. Adaptation and inhibition control pathological synchronization in a model of focal epileptic seizure // eNeuro. 2018. Vol. 0019-18. P. 1-14. doi
Martín-Luengo B., Myachykov A., Shtyrov Y. Neurocognitive Aspects of Language Function and Use // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. P. 189-190. doi
Bermúdez-Margaretto B., Beltrán D., Cuetos F., Dominguez A. Brain electrical signatures of novel word lexicalization // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. No. 2. P. 246-256. doi
Bermúdez-Margaretto B., Beltrán D., Cuetos F., Dominguez A. Brain Signatures of New ( Pseudo -) Words : Visual Repetition in Associate and Non-associative Contexts // Frontiers in Human Neuroscience. 2018. Vol. 12. No. 354. P. 1-12. doi
Ukraintseva Y., Liaukovich K., Polishchuk A., Martynova O., Belov D., Simenel E., Meira e Cruz М., Nizhnik A. Slow-wave sleep and androgens: selective slow-wave sleep suppression affects testosterone and 17α- hydroxyprogesterone secretion // Sleep Medicine. 2018. Vol. 148. P. 117-126. doi
Martín-Luengo B., Vorobyova A., Feurra M., Myachykov A., Shtyrov Y. Selective Social Context-Dependent Role of the Left Medial Prefrontal Cortex in Communication Exchanges, in: Neurobiology of Speech and Language. Proceedings of the 2nd International Workshop. St. Petersburg : Scifiya-print, 2018. Ch. 2. P. 16-16.
Уланов М. А., Штыров Ю. Ю., Строганова Т. А. TRANSCRANIAL DIRECT CURRENT STIMULATION AS A TOOL TO INDUCE LANGUAGE RECOVERY IN PATIENTS WITH POST-STROKE APHASIA // Журнал высшей нервной деятельности им. И.П. Павлова. 2018. Т. 68. № 6. С. 703-718. doi
Pokhoday M., Scheepers C., Shtyrov Y., Myachykov A. Motor (but not auditory) attention affects syntactic choice // Plos One. 2018. Vol. 13. No. 4. P. 1-12. doi
Pokhoday M., Myachykov A. Effects of Auditory and Visual Cueing of Attention on Syntactic Choice in Sentence Production. // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. No. 2. P. 209-221.
Myachykov A., Pokhoday M., Tomlin R. Attention and structural choice in sentence production, in: Oxford handbook of Psycholinguistics. Oxford : Oxford University Press, 2018. doi Ch. 2. P. 1-24. doi
Ulanov M., Stroganova T., Shtyrov Y. LANGUAGE REHABILITATION IN CHRONIC POST-STROKE APHASIA: A NEUROSCIENTIFIC PERSPECTIVE // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. No. 2. P. 232-245. doi
Fusco G., Scandola M., Feurra M., Pavone E. F., Rossi S., Aglioti S. M. Midfrontal theta transcranial alternating current stimulation modulates behavioural adjustment after error execution // European Journal of Neuroscience. 2018. Vol. 48. No. 10. P. 3159-3170. doi
Украинцева Ю., Левкович К. М., Sake K., Полищук А., Мартынова О. В. Улучшение распознавания звуков после их предъявления во время сна. // Журнал высшей нервной деятельности им. И.П. Павлова. 2018. Т. 68. № 5. С. 614-626. doi
Myachykov A. Neurocognitive Aspects of Language Function and Use // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. P. 189-190. doi
Chemerisova E., Atanov M., Mikheev I., Martynova O. Classification of Verbal and Mathematical Mental Operations Based on the Power Spectral Density of EEG // Psychology. Journal of the Higher School of Economics. 2018. Vol. 15. No. 2. P. 268-278. doi
Zinchenko O. O., Yaple Z., Arsalidou M. Brain Responses to Dynamic Facial Expressions: A Normative Meta-Analysis // Frontiers in Human Neuroscience. 2018. Vol. 12. P. 1-9. doi