Tag "microRNA"

A press release has been released on the HSE website (https://www.hse.ru/news/science/1152167635.html) based on an article about the unique properties of miR-93-5p microRNA (published in the journal PeerJ https://peerj.com/articles/20642/). HSE researchers have discovered an atypical behavior of oncogenic miR-93-5p microRNA in prostate cancer. It turned out that its various isoforms do not change the spectrum of target genes, but rather enhance each other's effects.

On 27 February 2026, Anton P. Zhiyanov, a research fellow at the Laboratory of Molecular Physiology, Faculty of Biology and Biotechnology, HSE University, successfully defended his dissertation “Methods for Evaluating the Quality of Linear Classifiers for microRNA Sequence Analysis” before the HSE University Dissertation Council in Computer Science. The thesis develops an axiomatic framework for comparing classification metrics, proposes new statistical tools for verifying linear classifiers, and applies them to the bioinformatics problem of microRNA isoform prediction. By its decision of 26 March 2026, the Dissertation Council conferred the sought-after degree on Anton.

miR-93-5p microRNA in prostate cancer retains a similar set of targets even with the formation of 5’ isoforms. This indicates the stability of its regulatory function to structural variations.