Tag "microfluidic chip"

Applied Biochemistry and Microbiology has published an article by researchers from the Molecular Physiology Laboratory at HSE University and the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, dedicated to optimizing the gas permeability of polydimethylsiloxane (PDMS)—a material widely used for manufacturing microfluidic chips in organ-on-a-chip systems.

In the article “Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies,” Russian scientists have presented an overview of modern cellular models of preeclampsia—a dangerous pregnancy complication. The study covers two-dimensional and three-dimensional cultures, as well as advanced placenta-on-a-chip microfluidic technologies, allowing the examination of pathological mechanisms at the cellular level. The paper highlights the potential of CRISPR-Cas9 and personalized models for developing new diagnostic and therapeutic methods for preeclampsia. These advancements open prospects for more precise early diagnosis of preeclampsia and the creation of effective treatment strategies.