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Tag "isomiR"

HSE Laboratory Research Fellow Anton Zhiyanov Successfully Defends PhD Thesis in Computer Science

A linear classifier distinguishing between homogeneous and heterogeneous cleavage at the 5′ end of the 3′ arm based on the nucleotide sequence in the region of the microRNA cleavage position
On 27 February 2026, Anton P. Zhiyanov, a research fellow at the Laboratory of Molecular Physiology, Faculty of Biology and Biotechnology, HSE University, successfully defended his dissertation “Methods for Evaluating the Quality of Linear Classifiers for microRNA Sequence Analysis” before the HSE University Dissertation Council in Computer Science. The thesis develops an axiomatic framework for comparing classification metrics, proposes new statistical tools for verifying linear classifiers, and applies them to the bioinformatics problem of microRNA isoform prediction. By its decision of 26 March 2026, the Dissertation Council conferred the sought-after degree on Anton.
Education achievements bioinformatics centers of excellence isomiR Linear classifiers machine learning microRNA Laboratory of Molecular Physiology
March 27

The manuscript of the Laboratory of Microphysiological Systems team has been accepted for publication

Graphical abstract
Our results show that the design of shRNA affects its processing by RNase-III Dicer and can result in the generation of undesirable 5'-isoforms of miRNA/siRNA encoded within the shRNA. This effect is especially significant for miRNA/siRNA longer than 19 nt.
isomiR International Laboratory of Microphysiological Systems
June 17, 2024