Alexander Tonevitsky

Publications⁷³

• Article M. O. Silkina, A. V. Razumovskaya, S. V. Nikulin, A. G. Tonevitsky, Alekseev B. Y. Assessing the Efficacy of Anti-Cancer Drugs on Organoid Models Derived from Prostate Cancer // Doklady Biochemistry and Biophysics. 2024 doi
• Article Vladimir Staroverov, Alexei Galatenko, Evgeny Knyazev, Alexander Tonevitsky. Mathematical model explains differences in Omicron and Delta SARS-CoV-2 dynamics in Caco-2 and Calu-3 cells // PeerJ. 2024. Vol. 12. Article e16964. doi
• Article Everest-Dass A., Nersisyan S., Maar H., Novosad V., Schröder-Schwarz J., Freytag V., Stuke J. L., Tonevitsky A., Maltseva D. Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer // Molecular Oncology. 2024. Vol. 18. No. 1. P. 62-90. doi
• Article Makarova J., Maltseva D., Tonevitsky A. Challenges in Characterization of Transcriptomes of Extracellular Vesicles and Non-Vesicular Extracellular RNA Carriers // Frontiers in Molecular Biosciences. 2023. Vol. 10. Article 1327985. doi
• Article Staroverov V., Nersisyan S., Galatenko A. V., Alekseev D., Lukashevich S., Polyakov F., Anisimov N., Tonevitsky A. Development of a novel mathematical model that explains SARS-CoV-2 infection dynamics in Caco-2 cells // PeerJ. 2023. Vol. 11. Article e14828. doi
• Article Zhiyanov A., Narek Engibaryan, Nersisyan S., Shkurnikov M., Tonevitsky A. Differential co-expression network analysis with DCoNA reveals isomiR targeting aberrations in prostate cancer // Bioinformatics. 2023. Vol. 39. No. 2. Article btad051. doi
• Article Nikulin S., Razumovskaya A., Poloznikov A., Zakharova G., Alekseev B., Tonevitsky A. ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis // Frontiers in Molecular Biosciences. 2023. Vol. 10. Article 1075704. doi
• Article Shkurnikov M., Nersisyan S., Averinskaya D., Chekova M., Poljakov F., Tonevitsky A. HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire // PeerJ. 2023. Vol. 11. Article e14707. doi
• Article Lebedeva S., Margaryan A., Smolyarchuk E., Nedorubov A., Materenchuk M., Tonevitsky A., Mutig K. Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease // Frontiers in Endocrinology. 2023. Vol. 14. Article 1176199. doi
• Article Tonevitsky A. Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease // Frontiers in Endocrinology. 2023. Vol. 14. P. 1-10. doi
• Article Maltseva D., Tonevitsky A. RNA-binding proteins regulating the CD44 alternative splicing // Frontiers in Molecular Biosciences. 2023. Vol. 10. Article 1326148. doi
• Article Zhiyanov A., Shkurnikov M., Nersisyan A., Hui C., Baranova A., Tonevitsky A. The signature of SARS-CoV-2 evolution reflects selective pressures within human guts // Journal of Medical Virology. 2023. Vol. 95. No. 8. Article e28996. doi
• Article Разумовская А. В., Силкина М. О., Никулин С. В., Тоневицкий А. Г., Алексеев Б. Я. Модуляторы сигнального пути Nrf2 усиливают цитотоксический эффект стандартных химиотерапевтических препаратов на органоиды метастатического колоректального рака / Пер. с англ. // Клеточные технологии в биологии и медицине. 2023. № 4. С. 283-288. doi
• Article Nersisyan S., Zhiyanov A., Еngibaryan N., Maltseva D., Tonevitsky A. A novel approach for a joint analysis of isomiR and mRNA expression data reveals features of isomiR targeting in breast cancer // Frontiers in Genetics. 2022. Vol. 13. Article 1070528. doi
• Article Vitobello A., Mazel B., Lelianova V. G., Zangrandi A., Petitto E., Suckling J., Salpietro V., Alexander G. Tonevitsky, Yuri Ushkaryov. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model // American Journal of Human Genetics. 2022. Vol. 109. No. 8. P. 1436-1457. doi
• Article Nersisyan S., Zhiyanov A., Zakharova M., Ishina I., Kurbatskaia I., Mamedov A., Galatenko A. V., Shkurnikov M., Gabibov A., Tonevitsky A. Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules // PeerJ. 2022. Vol. 10. Article e13354. doi
• Article Volynsky P., Maltseva D., Tabakmakher V., Bocharov E. V., Raygorodskaya M., Zakharova G., Britikova E., Tonevitsky A., Efremov R. Differences in medium-induced conformational plasticity presumably underlie different cytotoxic activity of ricin and viscumin // Biomolecules. 2022. Vol. 12. No. 2. Article 295. doi
• Article Nersisyan S., Novosad V., Galatenko A. V., Sokolov A., Bokov G., Konovalov A., Alekseev D., Tonevitsky A. ExhauFS: exhaustive search-based feature selection for classification and survival regression // PeerJ. 2022. Vol. 10. Article e13200. doi
• Article Nersisyan S, Novosad V., Galatenko A. V., Соколов А. П., Bokov G., Konovalov A., Alekseev D., Tonevitsky A. ExhauFS: exhaustive search-based feature selection for classification and survival regression // PeerJ. 2022. Vol. 10. No. n/a doi
• Article Titov A., Shaykhutdinova R., Shkurnikov M., Nersisyan S., Tonevitsky A. Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2 // JCI insight. 2022. Vol. 7. No. 9. Article e157699. doi
• Article Nersisyan S., Ahlers A., Lange T., Wicklein D., Galatenko A. V., Maltseva D., Raigorodskaya M., Makarova J., Tonevitsky A. Low expression of CD24 is associated with poor survival in colorectal cancer // Biochimie. 2022. Vol. 192. P. 91-101. doi
• Article Chen L., Nersisyan S., Wu C., Chang C., Tonevitsky A. On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron // Journal of Autoimmunity. 2022. Vol. 133. Article 102952. doi
• Article Shilova N., Bovin N., Maltseva D., Polyakova S., Sablina M., Niwa H., Zakharova G., Raigorodskaya M., Bufeeva L., Tonevitsky A. Specificity of viscumin revised. As probed with a printed glycan array // Biochimie. 2022. Vol. 202. P. 94-102. doi
• Article Nersisyan S., Zhiyanov A., Shkurnikov M., Tonevitsky A. T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations // Nucleic Acids Research. 2022. Vol. 50. No. D1. P. D883-D887. doi
• Article Nersisyan S., Gorbonos A., Alexey Makhonin, Zhiyanov A., Shkurnikov M., Tonevitsky A. isomiRTar: a comprehensive portal of pan-cancer 5′-isomiR targeting // PeerJ. 2022. Vol. 10. Article e14205. doi
• Article Poloznikov A., Nikulin S., Bolotina L., Kachmazov A., Raigorodskaya M., Kudryavtseva A., Bakhtogarimov I., Rodin S., Gaisina I., Topchiy M., Asachenko A., Novosad V., Tonevitsky A., Alekseev B. 9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells // Frontiers in Pharmacology. 2021. Vol. 12. Article 777114. doi
• Article Sabatier P., Beusch C. M., Maltseva D., Tonevitsky A., Zubarev R. A. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation // Nature Communications. 2021. No. 12. Article 6558. doi
• Article Shkurnikov M., Nersisyan S., Jankevic T., Galatenko A. V., Gordeev I., Vechorko V., Tonevitsky A. Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19 // Frontiers in Immunology. 2021. Vol. 12. Article 641900. doi
• Article Knyazev E. N., Paul S. Yu., Tonevitsky A. G. Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to Increased Expression of DDIT3 // Doklady Biochemistry and Biophysics. 2021. Vol. 499. No. 1. P. 251-256. doi
• Article Nersisyan S., Novosad V., Engibaryan N., Ushkaryov Y., Nikulin S., Tonevitsky A. ECM–Receptor Regulatory Network and Its Prognostic Role in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 782699. doi
• Article Nikulin S., Zakharova G., Poloznikov A., Raigorodskaya M., Wicklein D., Schumacher U., Nersisyan S., Bergquist J., Bakalkin G., Astakhova L., Tonevitsky A. Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells // Frontiers in Genetics. 2021. Vol. 12. Article 662843. doi
• Article Knyazev E., Nersisyan S., Tonevitsky A. Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue Barriers // Frontiers in Immunology. 2021. Vol. 12. Article 636966. doi
• Article J. Makarova, Turchinovich A., M. Shkurnikov, A. Tonevitsky. Extracellular miRNAs and cell-cell communication: problems and prospects // Trends in Biochemical Sciences. 2021. Vol. 46. No. 8. P. 640-651. doi
• Article Arnold S., Cortland J., Maltseva D., Nersisyan S., Tonevitsky A., Struken C. Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer // Journal of Cancer Research and Clinical Oncology. 2021. Vol. 148. No. 6. P. 1525-1542. doi
• Article Poloznikov A., Nersisyan S., Hushpulian D., Kazakov E., Tonevitsky A., Kazakov S., Vechorko V., Nikulin S., Makarova J., Gazaryan I. G. HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons // Frontiers in Pharmacology. 2021. Vol. 11. Article 621054. doi
• Article Zhiyanov A., Nersisyan S., Tonevitsky A. Hairpin sequence and structure is associated with features of isomiR biogenesis // RNA Biology. 2021. Vol. 18. No. sup1. P. 430-438. doi
• Article Nersisyan S., Galatenko A. V., Chekova M., Tonevitsky A. Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 662468. doi
• Article Nersisyan S., Galatenko A. V., Galatenko V. V., Shkurnikov M., Tonevitsky A. miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence // Plos One. 2021. Vol. 16. No. 4. Article e0249424. doi
• Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
• Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
• Article Maltseva D., Raygorodskaya М., Knyazev E., Zgoda V., Tikhonova O., Zaidi S., Nikulin S., Baranova A., Turchinovich A., Rodin S., Tonevitsky A. Knockdown of the α5 Laminin Chain Affects Differentiation of Colorectal Cancer Cells and Their Sensitivity to Chemotherapy // Biochimie. 2020. Vol. 174. P. 107-116. doi
• Article Nersisyan S., Engibaryan N., Gorbonos A., Kirdey K., Makhonin A., Tonevitsky A. Potential role of cellular miRNAs in coronavirus-host interplay // PeerJ. 2020. Vol. 8. Article e9994. doi
• Article Lange T., Samatov T., Galatenko V., Steffen P., von Kriegstein H., Spethmann T., Wicklein D., Maar H., Kupfernagel K., Labitzky V., Hanika S., Starzonek S., Ahlers A., Riecken K., Simon R., Polonski A., Sauter G., Schlomm T., Huland H., Johnsen S., Schlüter H., Tonevitsky A., Schumacher U. Xenograft-derived mRNA/miR and protein interaction networks of systemic dissemination in human prostate cancer // European Journal of Cancer. 2020. Vol. 137. P. 93-107. doi
• Article Нерсисян С. А., Галатенко А. В., Мальцева Д. В., Ушкарев Ю. А., Тоневицкий А. Г. Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии // Вестник Российского государственного медицинского университета. 2020. № 6. С. 48-54. doi
• Article Tonevitsky A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR‐122 into circulation // Obesity Reviews. 2019. Vol. 20. No. 1. P. 108-118. doi
• Article Gerasimenko T., Nikulin S., Zakharova G., Poloznikov A., Petrov V., Baranova A., Tonevitsky A. Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues // Frontiers in Bioengineering and Biotechnology. 2019. Vol. 7. P. 474. doi
• Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Zaidi S., Baranova A., Schumacher U., Wicklein D., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 122. P. 1-7. doi
• Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
• Article Knyazev E., Zakharova G., Astakhova L., Tsypina I., Tonevitsky A., Sukhikh G. Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 321-325. doi
• Article Knyazev E. N., Petrov V., Gazizov I., Gerasimenko T. N., Tsypina I. M., Tonevitsky A. G., Sukhikh G. T. Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 369-372. doi
• Article Volynsky P., Nolde D.E., Zakharova G., Palmer R., Tonevitsky A., Efremov R.G. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell // Scientific Reports. 2019. Vol. 9. P. 413. doi
• Article Efremov R., Нольде Д. Е., Волынский П. Е., Захарова Г. С., Palmer R. A., Tonevitsky A. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell. // Scientific Reports. 2019. Vol. 9. No. 413. P. 1-12. doi
• Article Sakharov D., Maltseva D., Knyazev E., Nikulin S., Poloznikov A., Shilin S., Baranova A., Tsypina I., Tonevitsky A. Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology // BMC Systems Biology. 2019. Vol. 13. No. 19. P. 3-11. doi
• Article Tonevitsky A. Transcriptome of Extracellular Vesicles: State-of-the-Art // Frontiers in Immunology. 2019. Vol. 10:202. P. 1-8. doi
• Article Tonevitsky A., Baranova A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor-suppressing, anti-fibrotic miR-122 into circulation // Obesity Reviews. 2018. P. 1-11. doi
• Article Turchinovich A., Baranova A., Drapkina O., Tonevitsky A. Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders // Frontiers in Physiology. 2018. Vol. 9. P. 1-13. doi
• Article Galatenko V. V., Galatenko A. V., Samatov T., Turchinovich A., Shkurnikov M., Makarova Julia A, Tonevitsky Alexander G. Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer // Scientific Reports. 2018. Vol. 8. Article 2418. doi
• Article Tonevitsky A., Maltseva D. Cumulative prognostic power of laminin genes in colorectal cancer // BMC Medical Genomics. 2018. Vol. 11. No. 1. P. 9. doi
• Article Tonevitsky A., Kononenko O., Mityakina I., Galatenko V., Watanabe H., Bazov I., Gerashchenko A., Sarkisyan D., Iatsyshyna A., Yakovleva T., Marklund N., Ossipov M. H., Bakalkin G. Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord // Brain Research. 2018. Vol. 1695. P. 78-83. doi
• Article Poloznikov A., Gazaryan I. G., Shkurnikov M., Nikulin S., Drapkina O., Baranova A., Tonevitsky A. In vitro and in silico liver models: Current trends, challenges and opportunities // ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2018. Vol. 35. No. 3. P. 397-412. doi
• Article Ernst A., Putscher A., Samatov T. R., Suling A., Galatenko, V. V., Shkurnikov, M. Y., Knyazev, E. N., Tonevitsky, A. G., Haalck T., Lange T., Schröder-Schwarz J., Riecken K., Schumacher U., Wicklein D. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy // Plos One. 2018. Vol. 13. No. 2. Article e0192525. doi
• Article Ivashchenko D. V., Rudik A. V., Poloznikov A., Nikulin S., Smirnov V. V., Tonevitsky A., Bryun E. A., Sychev D. A. Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies // Drug Metabolism and Personalized Therapy. 2018. Vol. 33. No. 2. P. 65-73. doi
• Article Князев Е. Н., Захарова Г. С., Астахова Л. А., Цыпина И. М., Тоневицкий А. Г. Метаболическое перепрограммирование трофобласта при моделировании ответа на гипоксию // Бюллетень экспериментальной биологии и медицины. 2018. Т. 9. № 166. С. 290-295. doi
• Article Alekseev B., Knyazev E., Shkurnikov M., Mikhailenko D., Zotikov A., Nyushko K., Tonevitsky A., Kaprin A. Panel of 6 microRNAs for minimally invasive diagnosis of prostate cancer // Journal of Urology. 2017. Vol. 197. No. 4S. P. e341. doi
• Article Maltseva D., Tonevitsky A. Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 13. P. E2758-E2765. doi
• Article Tonevitsky A., Maltseva D. Selectin-independent adhesion during ovarian cancer metastasis // Biochimie. 2017. Vol. 142. P. 197-206. doi
• Article Maltseva D., Tonevitsky A., Gabibov A. The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus // Molecules. 2017. Vol. 22. No. 5. P. E808. doi
• Article Samatov T., Galatenko V. V., Senyavina N., Galatenko A. V., Shkurnikov M., Tonevitskaya S., Sakharov D., Marx U., Ehrlich H., Schumacher U., Tonevitsky A. miRNA-mediated expression switch of cell adhesion genes driven by microcirculation in chip // Biochip Journal. 2017. No. 11. P. 262-269. doi
• Article Samatov T., Senyavina N., Galatenko V. V., Trushkin E., Aleksandrov D., Shibukhova G., Tonevitskaya S., Schumacher U., Tonevitsky A. Tumour-like Druggable Gene Expression Pattern of CaCo2 Cells in Microfluidic Chip // Biochip Journal. 2016. Vol. 10. No. 3. P. 215-220. doi
• Article Samatov T., Tonevitskaya S., Shkurnikov M., Tonevitsky A. Modeling the metastatic cascade by in vitro microfluidic platforms // Progress in Histochemistry and Cytochemistry. 2015. Vol. 49. No. 4. P. 21-29. doi
• Article Maltseva D., Tonevitsky A. C-FOS suppresses ovarian cancer progression by changing adhesion // Britisch of Journal Cancer. 2014. Vol. 110. No. 3. P. 753-763. doi
• Article Maltseva D., Tonevitsky A. Exercise Immunology Meets MiRNAs // Exercise Immunology Review. 2014. Vol. 20. P. 135-164.
• Article Maltseva D., Tonevitsky A. miRNome of inflammatory breast cancer // BMC Research Notes. 2014. Vol. 7. No. 1. P. 871-871. doi