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Analysis of Mg-binding Sites in RNA Structures

Student: Polina Tikhonova

Supervisor: Ivan I. Tsitovich

Faculty: Faculty of Computer Science

Educational Programme: Data Analysis for Biology and Medicine (Master)

Final Grade: 8

Year of Graduation: 2018

3D RNA structure is mainly determined by interactions between magnesium ions and RNA molecules and depending on the structure RNA plays different roles in living cells. Nowadays, there are not any efficient experimental methods, that can identify binding sites between magnesium ions in RNA molecules. The existing methods are too complicated to be applied to big structures. Thus, the question of ion binding sites prediction is still opened and remains topical. This problem can be solved by some computational and machine learning methods. The aim of this work is to find out efficiency of such methods and to analyze the existent ones.

Full text (added May 28, 2018)

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