Neural Basis of the Somatosensory Mismatch Negativity

Student: Moiseenko Olesya

Supervisor: Maria Del Carmen Herrojo-Ruiz

Faculty: Institute for Cognitive Neuroscience

Educational Programme: Cognitive Sciences and Technologies: From Neuron to Cognition (Master)

Year of Graduation: 2021

The Mismatch Negativity (MMN) is a neurophysiological signal reflecting the brain's automatic response to any sudden change. This signal can be evaluated with electroencephalography (EEG) or magnetoencephalography (MEG) by measuring the event-related responses or fields (ERP, ERF) locked to deviant stimuli embedded in a sequence of standard ones. Somatosensory MMN is not extensively researched yet it can offer a possibility to enrich knowledge on generation of MMN and its applications. It could also become an clinical marker for certain disorders as, interestingly, MMN can be impaired in one modality and be intact in another one. Somatosensory MMN is one of the windows for exploring these dysfunctions and uncovering their mechanisms. In this study we aimed at establishing characteristics of sMMN in response to electrical stimulation during movie viewing using MEG. We hope that procedure that we used to elicit sMMN could be further used in clinical populations, in particular, in children with arthrogryposis, a congenital disorder of musculoskeletal system.

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