Analisys of Geometric Cores in Structures of Complexes of Transcription Factors with DNA

The binding of DNA molecules to specific proteins is one of the most important processes in the cell. Currently, within the NPIDB database, there are more than 6,000 DNA-protein complexes are available for computer analysis. The analysis of these structural elements: the allocation of common structural elements - protein domains in DNA - protein complexes, which allow to advance in the understanding of these functions, as well as provide interaction between cells and regulation of internal processes, as well as the opportunity to participate in managing these processes at a new level. As part of the thesis, we proposed a method for constructing maps based on geometric structure of domains, based on the calculation of their structurally similar methods described. We applied to 6 family transcription factors in the state of nucleoprotein complexes. Standard and boundary values were identified. 6 families of DNA-binding domains of transcription factors were investigated and dis-clustered. Connection of the links of the program complex of the base of nucleoprotein complexes in a single pipeline, which allows determining structural proximity and building structural maps of any set of domains.