Diana Maltseva
- Associate Professor:Faculty of Biology and Biotechnology / Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Laboratory Head:Faculty of Biology and Biotechnology / International Laboratory of Microphysiological Systems
- Diana Maltseva has been at HSE University since 2020.
Education and Degrees
- 2009
Candidate of Sciences* (PhD)
Lomonosov Moscow State University - 2005
Specialist in Chemistry
Lomonosov Moscow State University, Department of Chemistry
According to the International Standard Classification of Education (ISCED) 2011, Candidate of Sciences belongs to ISCED level 8 - "doctoral or equivalent", together with PhD, DPhil, D.Lit, D.Sc, LL.D, Doctorate or similar. Candidate of Sciences allows its holders to reach the level of the Associate Professor.
Continuing education / Professional retraining / Internships / Study abroad experience
The additional professional program "Examination and registration of medicines", The Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation (2014 year)
The additional professional program "Organization and conduct of preclinical studies of drugs - GLP", The Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation (2014 year)
Awards and Accomplishments
Winner of the HSE University Best Russian Research Paper Competition – 2022
Courses (2023/2024)
Biochemistry (Bachelor’s programme; Faculty of Biology and Biotechnology; field of study "06.03.01. Биология", field of study "06.03.01. Биология"; 2 year, 1, 2 module)Rus
- Past Courses
Courses (2020/2021)
Publications37
- Article Everest-Dass A., Nersisyan S., Maar H., Novosad V., Schröder-Schwarz J., Freytag V., Stuke J. L., Tonevitsky A., Maltseva D. Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer // Molecular Oncology. 2024. Vol. 18. No. 1. P. 62-90. doi
- Article Makarova J., Maltseva D., Tonevitsky A. Challenges in Characterization of Transcriptomes of Extracellular Vesicles and Non-Vesicular Extracellular RNA Carriers // Frontiers in Molecular Biosciences. 2023. Vol. 10. Article 1327985. doi
- Article Maltseva D., Tonevitsky A. RNA-binding proteins regulating the CD44 alternative splicing // Frontiers in Molecular Biosciences. 2023. Vol. 10. Article 1326148. doi
- Article Новосад В. О., Мальцева Д. В. РНК-связывающие белки OAS1, ZFP36L2 и DHX58 вовлечены в регуляцию сплайсинга мРНК рецептора CD44 в клетках колоректального рака // Клеточные технологии в биологии и медицине. 2023. № 1. С. 1-6. (in press)
- Article Nersisyan S., Zhiyanov A., Еngibaryan N., Maltseva D., Tonevitsky A. A novel approach for a joint analysis of isomiR and mRNA expression data reveals features of isomiR targeting in breast cancer // Frontiers in Genetics. 2022. Vol. 13. Article 1070528. doi
- Article Volynsky P., Maltseva D., Tabakmakher V., Bocharov E. V., Raygorodskaya M., Zakharova G., Britikova E., Tonevitsky A., Efremov R. Differences in medium-induced conformational plasticity presumably underlie different cytotoxic activity of ricin and viscumin // Biomolecules. 2022. Vol. 12. No. 2. Article 295. doi
- Article Maltseva D., Polikanova I., Tonevitsky n., Novosad n. Expression of CD44 Isoforms in Tumor Samples and Cell Lines of Human Colorectal Cancer // Bulletin of Experimental Biology and Medicine. 2022. Vol. 173. No. 1. P. 155-159. doi
- Article Nersisyan S., Ahlers A., Lange T., Wicklein D., Galatenko A. V., Maltseva D., Raigorodskaya M., Makarova J., Tonevitsky A. Low expression of CD24 is associated with poor survival in colorectal cancer // Biochimie. 2022. Vol. 192. P. 91-101. doi
- Article Shilova N., Bovin N., Maltseva D., Polyakova S., Sablina M., Niwa H., Zakharova G., Raigorodskaya M., Bufeeva L., Tonevitsky A. Specificity of viscumin revised. As probed with a printed glycan array // Biochimie. 2022. Vol. 202. P. 94-102. doi
- Article Новосад В. О., Мальцева Д. В., Тоневицкий Е. А., Поликанова И. С. ЭКСПРЕССИЯ ИЗОФОРМ CD44 В ОПУХОЛЯХ И КЛЕТОЧНЫХ ЛИНИЯХ КОЛОРЕКТАЛЬНОГО РАКА ЧЕЛОВЕКА // Клеточные технологии в биологии и медицине. 2022. С. 49-54. doi
- Article Sabatier P., Beusch C. M., Maltseva D., Tonevitsky A., Zubarev R. A. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation // Nature Communications. 2021. No. 12. Article 6558. doi
- Article Arnold S., Cortland J., Maltseva D., Nersisyan S., Tonevitsky A., Struken C. Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer // Journal of Cancer Research and Clinical Oncology. 2021. Vol. 148. No. 6. P. 1525-1542. doi
- Article Knyazev E., Maltseva D., Raigorodskaya M., Shkurnikov M. HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease // Frontiers in Genetics. 2021. Vol. 12. Article 791640. doi
- Article Shkurnikov M. Yu., Nersisyan S. A., Osepyan A. S., Maltseva D. V., Knyazev E. N. Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 208-210. doi
- Article Maltseva D. V., Raigorodskaya M. P., Zgoda V. G., Tonevitsky E. A., Knyazev E. N. Intracellular Transport of Ribosome-Inactivating Proteins Depends on Annexin 13 // Doklady Biochemistry and Biophysics. 2020. Vol. 494. No. 1. P. 219-221. doi
- Article Maltseva D., Raygorodskaya М., Knyazev E., Zgoda V., Tikhonova O., Zaidi S., Nikulin S., Baranova A., Turchinovich A., Rodin S., Tonevitsky A. Knockdown of the α5 Laminin Chain Affects Differentiation of Colorectal Cancer Cells and Their Sensitivity to Chemotherapy // Biochimie. 2020. Vol. 174. P. 107-116. doi
- Article Maltseva D. V., Raigorodskaya M. P., Tikhonova O. V., Knyazev E. N., Tonevitsky E. A. Relationship between the Expression Level of PSMD11 and Other Proteasome Proteins with the Activity of Ricin and Viscumin // Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 198-200. doi
- Article Нерсисян С. А., Галатенко А. В., Мальцева Д. В., Ушкарев Ю. А., Тоневицкий А. Г. Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии // Вестник Российского государственного медицинского университета. 2020. № 6. С. 48-54. doi
- Article Мальцева Д. В., Райгородская М. П., Тихонова О. В., Князев Е. Н., Тоневицкий Е. А. Взаимосвязь уровня экспрессии PSMD11 и других белков протеасомы с уровнем инактивации рибосом рицином и вискумином // Доклады академии наук. Науки о жизни. 2020. Т. 493. С. 373-375. doi
- Article Мальцева Д. В., Райгородская М. П., Згода В. Г., Тоневицкий Е. А., Князев Е. Н. Внутриклеточный транспорт рибосом-инактивирующих белков зависит от аннексина 13 // Доклады академии наук. Науки о жизни. 2020. Т. 494. С. 444-447. doi
- Article Мальцева Д. В., Шкурников М. Ю., Нерсисян С. А., Никулин С. В., Курносов А. А., Райгородская М. П., Осипьянц А. И., Тоневицкий Е. А. Гипоксия усиливает трансцитоз в энтероцитах кишечника // Вестник Российского государственного медицинского университета. 2020. № 4. С. 62-69. doi
- Article Tonevitsky A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR‐122 into circulation // Obesity Reviews. 2019. Vol. 20. No. 1. P. 108-118. doi
- Article Mal'tseva D.V., Makarova Yu. A., Raigorodskaya M., Rodin S. Effects of Laminins 332 and 411 on the Epithelial—Mesenchymal Status of Colorectal Cancer Cells // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 377-382. doi
- Article Makarova J.A., Maltseva D.V., Khristichenko A. Y., Tsypina I.M., Tonevitsky E., Rodin S. Epithelial to Mesenchymal Transition Marker in 2D and 3D Colon Cancer Cell Cultures in the Presence of Laminin 332 and 411 // Molecular Biology. 2019. Vol. 53. P. 291-298. doi
- Article Knyazev E., Khristichenko A., Maltseva D., Gerasimenko T., Kindeeva O., Petrov V., Sakharov D. Placenta-on-a-chip model for assessing the transport and toxicity of xenobiotics in vitro // Placenta. 2019. Vol. 83. P. e59-e60. doi
- Article Sakharov D., Maltseva D., Knyazev E., Nikulin S., Poloznikov A., Shilin S., Baranova A., Tsypina I., Tonevitsky A. Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology // BMC Systems Biology. 2019. Vol. 13. No. 19. P. 3-11. doi
- Article Knyazev E. N., Nikulin S. V., Khristichenko A. Y., Gerasimenko T. N., Kindeeva O. V., Petrov V. A., Belyakova G. A., Maltseva D. V. Transport and toxicity of 5-fluorouracil, doxorubicin, and cyclophosphamide in in vitro placental barrier model based on BeWo b30 cells // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. P. 2344-2349. doi
- Article Tonevitsky A., Maltseva D. Cumulative prognostic power of laminin genes in colorectal cancer // BMC Medical Genomics. 2018. Vol. 11. No. 1. P. 9. doi
- Article Knyazev E., Poloznikov A., Maltseva D., Khristichenko A. Oxyquinoline derivative activates HIF-1 and increases transepithelial resistance of BeWo b30 monolayer // Placenta. 2018. Vol. 69. P. e47. doi
- Article Мальцева Д. В. Ламинины и метастазирование опухолей // Молекулярная биология. 2018. Т. 52. № 3. С. 411-434. doi
- Article Maltseva D., Tonevitsky A. Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 13. P. E2758-E2765. doi
- Article Tonevitsky A., Maltseva D. Selectin-independent adhesion during ovarian cancer metastasis // Biochimie. 2017. Vol. 142. P. 197-206. doi
- Article Maltseva D., Tonevitsky A., Gabibov A. The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus // Molecules. 2017. Vol. 22. No. 5. P. E808. doi
- Article Sakharov D., Rudakovskaya P., Maltseva D., Trushkin E., Tonevitskaya S. Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity / Пер. с рус. // Bulletin of Experimental Biology and Medicine. 2016. Vol. 161. No. 1. P. 116-119. doi
- Article Maltseva D., Tonevitsky A. C-FOS suppresses ovarian cancer progression by changing adhesion // Britisch of Journal Cancer. 2014. Vol. 110. No. 3. P. 753-763. doi
- Article Maltseva D., Tonevitsky A. Exercise Immunology Meets MiRNAs // Exercise Immunology Review. 2014. Vol. 20. P. 135-164.
- Article Maltseva D., Tonevitsky A. miRNome of inflammatory breast cancer // BMC Research Notes. 2014. Vol. 7. No. 1. P. 871-871. doi
Conferences
- 2022I международная конференция «Генетические технологии в трансляционной биомедицине» (Томск). Presentation: Нокдаун а5 цепи ламининов приводит к частичной дедифференцировке клеток колоректального рака и увеличивает их чувствительность к химиотерапии
- 2021the Vth Sechenov International Biomedical Summit 2021 (SIBS-2021) (Москва). Presentation: Knockdown of CD44 prevents metastasis in HT-29 xenograft colorectal cancer model
Employment history
Head of Laboratory, International Laboratory of Microphysiological Systems, Faculty of Biology and Biotechnology, National Research University Higher School of Economics (2020 - present time)
Leading Researcher, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences (2019 - 2020)
Principal Investigator at Hertsen Moscow Oncology Research Center, Branch of Federal State Budgetary Institution National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Moscow, Russia (2018 - 2019)
Deputy director for Science at Scientific Research Center Bioclinicum, Moscow, Russia (2014 - 2018)
Group leader at Scientific Research Center Bioclinicum, Moscow, Russia (2012 - 2014)
Postdoctoral research at Department of Molecular Physiology, Russian Research Institute of Physical Education and Sport, Moscow, Russia (2009 - 2012)
Researcher, The A.N. Belozersky Institute Of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia (2008 - 2009)
Seminar: gene overexpressionSeminar
On June 24, 2022, the International Laboratory of Microphysiological Systems hosted a joint seminar with the Laboratory for Research on the Molecular Mechanisms of Longevity, dedicated to the issue of miRNA overexpression in human cells, a process that leads to an excess amount of transcript produced by the genome.
Biologists Figure Out How Stem Cells Turn Into Other Types of Cells at Molecular Level
An international team of researchers including biologists from HSE University has developed a method that helps obtain information on changes in protein expression and properties during cells’ transition from one state to another. One of the most interesting transitions is the transformation of cells from undifferentiated stem cells to differentiated cells of various organs and tissues. The paper was published in Nature Communications.
Members of the International Laboratory of Microphysiological Systems Took Part in SIBS-2021
The 5th Sechenov International Biomedical Summit (SIBS - 2021) was held on November 9-10, 2021 at FSAU VO Sechenov Russian Ministry of Health (Sechenov University). It is one of the most authoritative forums in the country in the field of advanced bioengineering, regenerative and personalized medicine.
Members of the International Laboratory of Microphysiological Systems and the Laboratory of Molecular Physiology participated in RECOMB 2021
25th International Conference on Research in Computational Molecular Biology (RECOMB 2021) was held online on August 29th - September 2nd. Staff of the Faculty of Biology and Biotechnology - Stepan Nersisyan, Alexey Galatenko, Diana Maltseva and Alexander Tonevitsky participated in a poster session with the report 'miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence'
International Laboratory of Microphysiological Systems at the conference 2020 - International Conference on Research inLife-Sciences & Healthcare (ICRLSH)
On December 11-12, 2020, employees of the International Laboratory of Microphysiological Systems made a presentation at the conference 2020 – International Conference on Research in Life-Sciences & Healthcare (ICRLSH), London, UK