Alexander Tonevitsky
- Dean:Faculty of Biology and Biotechnology
- Chief Research Fellow:International Laboratory of Microphysiological Systems
- Professor:Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Member of the HSE Academic Council
- Alexander Tonevitsky has been at HSE University since 2018.
Education, Degrees and Academic Titles
- 1995Professor
- 1993
Doctor of Sciences*
- 1985
Candidate of Sciences* (PhD)
- 1979
Degree in Biology
Lomonosov Moscow State University
According to the International Standard Classification of Education (ISCED) 2011, Candidate of Sciences belongs to ISCED level 8 - "doctoral or equivalent", together with PhD, DPhil, D.Lit, D.Sc, LL.D, Doctorate or similar. Candidate of Sciences allows its holders to reach the level of the Associate Professor.
A post-doctoral degree called Doctor of Sciences is given to reflect second advanced research qualifications or higher doctorates in ISCED 2011.
Courses (2019/2020)
Publications38
- Article Shkurnikov M., Nersisyan S., Tatjana J., Galatenko A. V., Ivan G., Valery V., Tonevitsky A. Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19 // Frontiers in Immunology. 2021. Vol. 12. Article 641900. doi
- Article J. Makarova, Turchinovich A., M. Shkurnikov, A. Tonevitsky. Extracellular miRNAs and cell-cell communication: problems and prospects // Trends in Biochemical Sciences. 2021 doi (in press)
- Article Poloznikov A., Nersisyan S., Hushpulian D., Kazakov E., Tonevitsky A., Kazakov S., Vechorko V., Nikulin S., Makarova J., Gazaryan I. HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons // Frontiers in Pharmacology. 2021. Vol. 11. Article 621054. doi
- Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
- Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
- Article Maltseva D., Raygorodskaya М., Knyazev E., Zgoda V., Tikhonova O., Zaidi S., Nikulin S., Baranova A., Turchinovich A., Rodin S., Tonevitsky A. Knockdown of the α5 Laminin Chain Affects Differentiation of Colorectal Cancer Cells and Their Sensitivity to Chemotherapy // Biochimie. 2020. Vol. 174. P. 107-116. doi
- Article Nersisyan S., Engibaryan N., Gorbonos A., Kirdey K., Makhonin A., Tonevitsky A. Potential role of cellular miRNAs in coronavirus-host interplay // PeerJ. 2020. Vol. 8. No. e9994. P. 1-16. doi
- Article Tonevitsky A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR‐122 into circulation // Obesity Reviews. 2019. Vol. 20. No. 1. P. 108-118. doi
- Article Gerasimenko T., Nikulin S., Zakharova G., Poloznikov A., Petrov V., Baranova A., Tonevitsky A. Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues // Frontiers in Bioengineering and Biotechnology. 2019. Vol. 7. P. 474. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Zaidi S., Baranova A., Schumacher U., Wicklein D., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 122. P. 1-7. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
- Article Knyazev E., Zakharova G., Astakhova L., Tsypina I., Tonevitsky A., Sukhikh G. Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia / Пер. с рус. // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 321-325. doi
- Article Knyazev E., Petrov V., Gazizov I., Gerasimenko T. N., Tsypina I., Tonevitsky A., Sukhikh G. T. Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer / Пер. с рус. // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 369-372. doi
- Article Volynsky P., Nolde D.E., Zakharova G., Palmer R., Tonevitsky A., Efremov R.G. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell // Scientific Reports. 2019. Vol. 9. P. 413. doi
- Article Efremov R., Нольде Д. Е., Волынский П. Е., Захарова Г. С., Palmer R. A., Tonevitsky A. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell. // Scientific Reports. 2019. Vol. 9. No. 413. P. 1-12. doi
- Article Tonevitsky A., Tsypina I., Sakharov D. A., Knyazev E., Poloznikov A., Shilin S. A., Baranova A., Maltseva D., Nikulin S. Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology // BMC Systems Biology. 2019. Vol. 13. No. 19. P. 3-11. doi
- Article Tonevitsky A. Transcriptome of Extracellular Vesicles: State-of-the-Art // Frontiers in Immunology. 2019. Vol. 10:202. P. 1-8. doi
- Article Tonevitsky A., Baranova A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor-suppressing, anti-fibrotic miR-122 into circulation // Obesity Reviews. 2018. P. 1-11. doi
- Article Turchinovich A., Baranova A., Drapkina O., Tonevitsky A. Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders // Frontiers in Physiology. 2018. Vol. 9. P. 1-13. doi
- Article Galatenko Vladimir V., Galatenko Alexey V., Samatov T. R., Turchinovich A. A., Shkurnikov M. Y., Makarova J. A., Tonevitsky Alexander G. Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer // Scientific Reports. 2018. Vol. 8. P. 2418:1-2418:12. doi
- Article Galatenko V. V., Galatenko A. V., Samatov T., Turchinovich A., Shkurnikov M., Makarova Julia A, Tonevitsky Alexander G. Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer // Scientific Reports. 2018. Vol. 8. Article 2418. doi
- Article Tonevitsky A., Maltseva D. Cumulative prognostic power of laminin genes in colorectal cancer // BMC Medical Genomics. 2018. Vol. 11. No. 1. P. 9. doi
- Article Tonevitsky A., Kononenko O., Mityakina I., Galatenko V., Watanabe H., Bazov I., Gerashchenko A., Sarkisyan D., Iatsyshyna A., Yakovleva T., Marklund N., Ossipov M. H., Bakalkin G. Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord // Brain Research. 2018. Vol. 1695. P. 78-83. doi
- Article Poloznikov A., Gazaryan I., Shkurnikov M., Nikulin S., Drapkina O., Baranova A., Tonevitsky A. In vitro and in silico liver models: Current trends, challenges and opportunities // ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2018. Vol. 35. No. 3. P. 397-412. doi
- Article Ernst A., Putscher A., Samatov T. R., Suling A., Galatenko, V. V., Shkurnikov, M. Y., Knyazev, E. N., Tonevitsky, A. G., Haalck T., Lange T., Schröder-Schwarz J., Riecken K., Schumacher U., Wicklein D. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy // Plos One. 2018. Vol. 13. No. 2. Article e0192525. doi
- Article Ivashchenko D. V., Rudik A. V., Poloznikov A., Nikulin S., Smirnov V. V., Tonevitsky A., Bryun E. A., Sychev D. A. Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies // Drug Metabolism and Personalized Therapy. 2018. Vol. 33. No. 2. P. 65-73. doi
- Article Князев Е. Н., Петров В. А., Газизов И. Н., Герасименко Т. Н., Цыпина И. М., Тоневицкий А. Г., Сухих Г. Т. Воздействие оксихинолина изменяет экспрессию генов клаудинов, что снижает барьерную функцию монослоя клеток BeWo b30 // Бюллетень экспериментальной биологии и медицины. 2018. Т. 166. № 9. С. 342-346.
- Article Князев Е. Н., Захарова Г. С., Астахова Л. А., Цыпина И. М., Тоневицкий А. Г. Метаболическое перепрограммирование трофобласта при моделировании ответа на гипоксию // Бюллетень экспериментальной биологии и медицины. 2018. Т. 9. № 166. С. 290-295. doi
- Article Alekseev B., Knyazev E., Shkurnikov M., Mikhailenko D., Zotikov A., Nyushko K., Tonevitsky A., Kaprin A. Panel of 6 microRNAs for minimally invasive diagnosis of prostate cancer // Journal of Urology. 2017. Vol. 197. No. 4S. P. e341. doi
- Article Maltseva D., Tonevitsky A. Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 13. P. E2758-E2765. doi
- Article Tonevitsky A., Maltseva D. Selectin-independent adhesion during ovarian cancer metastasis // Biochimie. 2017. Vol. 142. P. 197-206. doi
- Article Maltseva D., Tonevitsky A., Gabibov A. The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus // Molecules. 2017. Vol. 22. No. 5. P. E808. doi
- Article Samatov T., Galatenko V. V., Senyavina N., Galatenko A. V., Shkurnikov M., Tonevitskaya S., Sakharov D., Marx U., Ehrlich H., Schumacher U., Tonevitsky A. miRNA-mediated expression switch of cell adhesion genes driven by microcirculation in chip // Biochip Journal. 2017. No. 11. P. 262-269. doi
- Article Samatov T., Senyavina N., Galatenko V. V., Trushkin E., Aleksandrov D., Shibukhova G., Tonevitskaya S., Schumacher U., Tonevitsky A. Tumour-like Druggable Gene Expression Pattern of CaCo2 Cells in Microfluidic Chip // Biochip Journal. 2016. Vol. 10. No. 3. P. 215-220. doi
- Article Samatov T., Tonevitskaya S., Shkurnikov M., Tonevitsky A. Modeling the metastatic cascade by in vitro microfluidic platforms // Progress in Histochemistry and Cytochemistry. 2015. Vol. 49. No. 4. P. 21-29. doi
- Article Maltseva D., Tonevitsky A. C-FOS suppresses ovarian cancer progression by changing adhesion // Britisch of Journal Cancer. 2014. Vol. 110. No. 3. P. 753-763. doi
- Article Maltseva D., Tonevitsky A. Exercise Immunology Meets MiRNAs // Exercise Immunology Review. 2014. Vol. 20. P. 135-164.
- Article Maltseva D., Tonevitsky A. miRNome of inflammatory breast cancer // BMC Research Notes. 2014. Vol. 7. No. 1. P. 871-871. doi
Editorial board membership
2016: Member of the Editorial Board (Frontiers in Chemistry and Molecular Biosciences), Member of the Editorial Board (Frontiers in Cell and Developmental Biology), Frontiers in Biology.
2007: Member of the Editorial Board (Research and Review Insights ), Annual Research and Review in Biology.
2004: Member of the Editorial Board (American Journal of Leukemia Research), American Journal of Biomedical Sciences.
1992: Member of the Editorial Board, Бюллетень экспериментальной биологии и медицины (Bulletin of Experimental Biology and Medicine).
1991: Member of the Editorial Board, Клеточные технологии в биологии и медицине (Cell Technologies in Biology and Medicine).
1990: Deputy Editor-in-chief, Биотехнология.
Researchers Establish Intracellular Interaction Network in Breast Cancer
HSE University researchers have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE.
Researchers Reveal Genetic Predisposition to Severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.
Members of the International Laboratory of Microphysiological Systems and students of the Faculty of Biology and Biotechnology gave an interview to the correspondent of “MIR” TV company on the results of their study of molecules capable to suppress the replication of coronaviruses
Faculty of Biology and Biotechnology researchers in their interview to the correspondent of «MIR» TV company talked about their study on interactions between microRNA molecules and human coronaviruses.
Researchers Find Therapeutic Targets to Fight SARS-CoV-2
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.
Joint Seminar of HSE Faculty of Biology and Biotechnology and George Mason University
This June, first-year undergraduate students of the HSE Faculty of Biology and Biotechnology took part in an online seminar at George Mason University (USA). The seminar was part of the Coronavirus Research Update summer course, taught by Professor Ancha Baranova.
HSE and RAS Institutes to Produce Future Generations of Scientists
On February 12 at the Russian Ministry of Education and Science, HSE and five institutes of the Russian Academy of Sciences (RAS) signed agreements to collaborate in the field of scientific education. The institutions have pledged to contribute to the development of new faculties of chemistry as well as biology and biotechnology at HSE.
‘HSE Is in a Class by Itself.’ Annual HSE International Advisory Committee Meeting Commences
New faculties, personnel development, internationalisation, and much more – these are all things on the agenda of the annual International Advisory Committee (IAC) meeting currently taking place in Moscow.
Alexander Tonevitsky Recognized as Distinguished Scientist of Russia
Alexander Tonevitsky, Dean of the HSE Faculty of Biology and Biotechnologies and corresponding member of the RAS, was awarded the honorary title of Distinguished Scientist of the Russian Federation. The awards ceremony was held in the Kremlin on November 27.
HSE Opens Two New Faculties
In 2019, HSE will begin enrolling students in undergraduate programmes at two new faculties: the Faculty of Chemistry, and the Faculty of Biology and Biotechnology. These faculties will work in partnership with leading RAS institutions where students will be carrying out research.