Alexander Tonevitsky
- Dean:Faculty of Biology and Biotechnology
- Professor:Faculty of Biology and Biotechnology / Joint Department with RAS Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Chief Research Fellow:Faculty of Biology and Biotechnology / Laboratory for Research on Molecular Mechanisms of Longevit
- Programme Academic Supervisor:Bioeconomics
- Member of the HSE Academic Council
- Alexander Tonevitsky has been at HSE University since 2018.
Education, Degrees and Academic Titles
- 1995Professor
- 1993
Doctor of Sciences*
- 1985
Candidate of Sciences* (PhD)
- 1979
Degree in Biology
Lomonosov Moscow State University
According to the International Standard Classification of Education (ISCED) 2011, Candidate of Sciences belongs to ISCED level 8 - "doctoral or equivalent", together with PhD, DPhil, D.Lit, D.Sc, LL.D, Doctorate or similar. Candidate of Sciences allows its holders to reach the level of the Associate Professor.
A post-doctoral degree called Doctor of Sciences is given to reflect second advanced research qualifications or higher doctorates in ISCED 2011.
Courses (2021/2022)
- Mentor's Seminar (Master’s programme; Faculty of Biology and Biotechnology; 1 year, 1-4 module)Rus
- Reseach Seminar 2 (Bachelor’s programme; Faculty of Biology and Biotechnology; 3 year, 3, 4 module)Rus
- Past Courses
Courses (2019/2020)
Publications50
- Article Nersisyan S., Novosad V., Galatenko A. V., Соколов А., Боков Г., Коновалов А., Tonevitsky A., Alekseev D. ExhauFS: exhaustive search-based feature selection for classification and survival regression // PeerJ. 2022 doi
- Article Nersisyan S., Galatenko A. V., Maltseva D., Raigorodskaya M., Makarova J., Tonevitsky A. Low expression of CD24 is associated with poor survival in colorectal cancer // Biochimie. 2022. Vol. 192. P. 91-101. doi
- Article Nersisyan S., Zhiyanov A., Shkurnikov M., Tonevitsky A. T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations // Nucleic Acids Research. 2022. Vol. 50. No. D1. P. D883-D887. doi
- Article Poloznikov A., Nikulin S., Bolotina L., Kachmazov A., Raigorodskaya M., Kudryavtseva A., Bakhtogarimov I., Rodin S., Gaisina I., Topchiy M., Asachenko A., Novosad V., Tonevitsky A., Alekseev B. 9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells // Frontiers in Pharmacology. 2021. Vol. 12. Article 777114. doi
- Article Sabatier P., Beusch C. M., Maltseva D., Tonevitsky A., Zubarev R. A. An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation // Nature Communications. 2021. No. 12. Article 6558. doi
- Article Shkurnikov M., Nersisyan S., Jankevic T., Galatenko A. V., Gordeev I., Vechorko V., Tonevitsky A. Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19 // Frontiers in Immunology. 2021. Vol. 12. Article 641900. doi
- Article Knyazev E. N., Paul S. Yu., Tonevitsky A. G. Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to Increased Expression of DDIT3 // Doklady Biochemistry and Biophysics. 2021. Vol. 499. No. 1. P. 251-256. doi
- Article Nersisyan S., Novosad V., Engibaryan N., Ushkaryov Y., Nikulin S., Tonevitsky A. ECM–Receptor Regulatory Network and Its Prognostic Role in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 782699. doi
- Article Nikulin S., Zakharova G., Poloznikov A., Raigorodskaya M., Wicklein D., Schumacher U., Nersisyan S., Bergquist J., Bakalkin G., Astakhova L., Tonevitsky A. Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells // Frontiers in Genetics. 2021. Vol. 12. Article 662843. doi
- Article Knyazev E., Nersisyan S., Tonevitsky A. Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue Barriers // Frontiers in Immunology. 2021. Vol. 12. Article 636966. doi
- Article J. Makarova, Turchinovich A., M. Shkurnikov, A. Tonevitsky. Extracellular miRNAs and cell-cell communication: problems and prospects // Trends in Biochemical Sciences. 2021. Vol. 46. No. 8. P. 640-651. doi
- Article Arnold S., Cortland J., Maltseva D., Nersisyan S., Tonevitsky A., Struken C. Fra-2 Overexpression Upregulates Pro-metastatic Cell-adhesion Molecules, Promotes Pulmonary Metastasis and Reduces Survival in a Spontaneous // Journal of Cancer Research and Clinical Oncology. 2021. Article 1. doi
- Article Poloznikov A., Nersisyan S., Hushpulian D., Kazakov E., Tonevitsky A., Kazakov S., Vechorko V., Nikulin S., Makarova J., Gazaryan I. G. HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons // Frontiers in Pharmacology. 2021. Vol. 11. Article 621054. doi
- Article Zhiyanov A., Nersisyan S., Tonevitsky A. Hairpin sequence and structure is associated with features of isomiR biogenesis // RNA Biology. 2021. Vol. 18. No. sup1. P. 430-438. doi
- Article Nersisyan S., Galatenko A. V., Chekova M., Tonevitsky A. Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer // Frontiers in Genetics. 2021. Vol. 12. Article 662468. doi
- Article Nersisyan S., Galatenko A. V., Galatenko V. V., Shkurnikov M., Tonevitsky A. miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence // Plos One. 2021. Vol. 16. No. 4. Article e0249424. doi
- Article Nersisyan S., Shkurnikov M., Poloznikov A., Turchinovich A., Burwinkel B., Anisimov N., Tonevitsky A. A post-processing algorithm for miRNA microarray data // International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228. doi
- Article Nersisyan S., Shkurnikov M., Turchinovich A., Knyazev E., Tonevitsky A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 // Plos One. 2020. Vol. 15. No. 7. P. e0235987. doi
- Article Maltseva D., Raygorodskaya М., Knyazev E., Zgoda V., Tikhonova O., Zaidi S., Nikulin S., Baranova A., Turchinovich A., Rodin S., Tonevitsky A. Knockdown of the α5 Laminin Chain Affects Differentiation of Colorectal Cancer Cells and Their Sensitivity to Chemotherapy // Biochimie. 2020. Vol. 174. P. 107-116. doi
- Article Nersisyan S., Engibaryan N., Gorbonos A., Kirdey K., Makhonin A., Tonevitsky A. Potential role of cellular miRNAs in coronavirus-host interplay // PeerJ. 2020. Vol. 8. Article e9994. doi
- Article Lange T., Samatov T., Galatenko V., Steffen P., von Kriegstein H., Spethmann T., Wicklein D., Maar H., Kupfernagel K., Labitzky V., Hanika S., Starzonek S., Ahlers A., Riecken K., Simon R., Polonski A., Sauter G., Schlomm T., Huland H., Johnsen S., Schlüter H., Tonevitsky A., Schumacher U. Xenograft-derived mRNA/miR and protein interaction networks of systemic dissemination in human prostate cancer // European Journal of Cancer. 2020. Vol. 137. P. 93-107. doi
- Article Tonevitsky A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR‐122 into circulation // Obesity Reviews. 2019. Vol. 20. No. 1. P. 108-118. doi
- Article Gerasimenko T., Nikulin S., Zakharova G., Poloznikov A., Petrov V., Baranova A., Tonevitsky A. Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues // Frontiers in Bioengineering and Biotechnology. 2019. Vol. 7. P. 474. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Zaidi S., Baranova A., Schumacher U., Wicklein D., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 122. P. 1-7. doi
- Article Shkurnikov M., Nikulin S., Nersisyan S., Poloznikov A., Tonevitsky A. LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer // Frontiers in Molecular Biosciences. 2019. Vol. 6. No. 8. P. 122. doi
- Article Knyazev E., Zakharova G., Astakhova L., Tsypina I., Tonevitsky A., Sukhikh G. Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 321-325. doi
- Article Knyazev E. N., Petrov V., Gazizov I., Gerasimenko T. N., Tsypina I. M., Tonevitsky A. G., Sukhikh G. T. Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer // Bulletin of Experimental Biology and Medicine. 2019. Vol. 166. No. 3. P. 369-372. doi
- Article Volynsky P., Nolde D.E., Zakharova G., Palmer R., Tonevitsky A., Efremov R.G. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell // Scientific Reports. 2019. Vol. 9. P. 413. doi
- Article Efremov R., Нольде Д. Е., Волынский П. Е., Захарова Г. С., Palmer R. A., Tonevitsky A. Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell. // Scientific Reports. 2019. Vol. 9. No. 413. P. 1-12. doi
- Article Sakharov D., Maltseva D., Knyazev E., Nikulin S., Poloznikov A., Shilin S., Baranova A., Tsypina I., Tonevitsky A. Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology // BMC Systems Biology. 2019. Vol. 13. No. 19. P. 3-11. doi
- Article Tonevitsky A. Transcriptome of Extracellular Vesicles: State-of-the-Art // Frontiers in Immunology. 2019. Vol. 10:202. P. 1-8. doi
- Article Tonevitsky A., Baranova A., Maltseva D. Adipose may actively delay progression of NAFLD by releasing tumor-suppressing, anti-fibrotic miR-122 into circulation // Obesity Reviews. 2018. P. 1-11. doi
- Article Turchinovich A., Baranova A., Drapkina O., Tonevitsky A. Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders // Frontiers in Physiology. 2018. Vol. 9. P. 1-13. doi
- Article Galatenko V. V., Galatenko A. V., Samatov T., Turchinovich A., Shkurnikov M., Makarova Julia A, Tonevitsky Alexander G. Comprehensive network of miRNA-induced intergenic interactions and a biological role of its core in cancer // Scientific Reports. 2018. Vol. 8. Article 2418. doi
- Article Tonevitsky A., Maltseva D. Cumulative prognostic power of laminin genes in colorectal cancer // BMC Medical Genomics. 2018. Vol. 11. No. 1. P. 9. doi
- Article Tonevitsky A., Kononenko O., Mityakina I., Galatenko V., Watanabe H., Bazov I., Gerashchenko A., Sarkisyan D., Iatsyshyna A., Yakovleva T., Marklund N., Ossipov M. H., Bakalkin G. Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord // Brain Research. 2018. Vol. 1695. P. 78-83. doi
- Article Poloznikov A., Gazaryan I. G., Shkurnikov M., Nikulin S., Drapkina O., Baranova A., Tonevitsky A. In vitro and in silico liver models: Current trends, challenges and opportunities // ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2018. Vol. 35. No. 3. P. 397-412. doi
- Article Ernst A., Putscher A., Samatov T. R., Suling A., Galatenko, V. V., Shkurnikov, M. Y., Knyazev, E. N., Tonevitsky, A. G., Haalck T., Lange T., Schröder-Schwarz J., Riecken K., Schumacher U., Wicklein D. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy // Plos One. 2018. Vol. 13. No. 2. Article e0192525. doi
- Article Ivashchenko D. V., Rudik A. V., Poloznikov A., Nikulin S., Smirnov V. V., Tonevitsky A., Bryun E. A., Sychev D. A. Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies // Drug Metabolism and Personalized Therapy. 2018. Vol. 33. No. 2. P. 65-73. doi
- Article Князев Е. Н., Захарова Г. С., Астахова Л. А., Цыпина И. М., Тоневицкий А. Г. Метаболическое перепрограммирование трофобласта при моделировании ответа на гипоксию // Бюллетень экспериментальной биологии и медицины. 2018. Т. 9. № 166. С. 290-295. doi
- Article Alekseev B., Knyazev E., Shkurnikov M., Mikhailenko D., Zotikov A., Nyushko K., Tonevitsky A., Kaprin A. Panel of 6 microRNAs for minimally invasive diagnosis of prostate cancer // Journal of Urology. 2017. Vol. 197. No. 4S. P. e341. doi
- Article Maltseva D., Tonevitsky A. Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 114. No. 13. P. E2758-E2765. doi
- Article Tonevitsky A., Maltseva D. Selectin-independent adhesion during ovarian cancer metastasis // Biochimie. 2017. Vol. 142. P. 197-206. doi
- Article Maltseva D., Tonevitsky A., Gabibov A. The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus // Molecules. 2017. Vol. 22. No. 5. P. E808. doi
- Article Samatov T., Galatenko V. V., Senyavina N., Galatenko A. V., Shkurnikov M., Tonevitskaya S., Sakharov D., Marx U., Ehrlich H., Schumacher U., Tonevitsky A. miRNA-mediated expression switch of cell adhesion genes driven by microcirculation in chip // Biochip Journal. 2017. No. 11. P. 262-269. doi
- Article Samatov T., Senyavina N., Galatenko V. V., Trushkin E., Aleksandrov D., Shibukhova G., Tonevitskaya S., Schumacher U., Tonevitsky A. Tumour-like Druggable Gene Expression Pattern of CaCo2 Cells in Microfluidic Chip // Biochip Journal. 2016. Vol. 10. No. 3. P. 215-220. doi
- Article Samatov T., Tonevitskaya S., Shkurnikov M., Tonevitsky A. Modeling the metastatic cascade by in vitro microfluidic platforms // Progress in Histochemistry and Cytochemistry. 2015. Vol. 49. No. 4. P. 21-29. doi
- Article Maltseva D., Tonevitsky A. C-FOS suppresses ovarian cancer progression by changing adhesion // Britisch of Journal Cancer. 2014. Vol. 110. No. 3. P. 753-763. doi
- Article Maltseva D., Tonevitsky A. Exercise Immunology Meets MiRNAs // Exercise Immunology Review. 2014. Vol. 20. P. 135-164.
- Article Maltseva D., Tonevitsky A. miRNome of inflammatory breast cancer // BMC Research Notes. 2014. Vol. 7. No. 1. P. 871-871. doi
Editorial board membership
2016: Member of the Editorial Board (Frontiers in Chemistry and Molecular Biosciences), Member of the Editorial Board (Frontiers in Cell and Developmental Biology), Frontiers in Biology.
2007: Member of the Editorial Board (Research and Review Insights ), Annual Research and Review in Biology.
2004: Member of the Editorial Board (American Journal of Leukemia Research), American Journal of Biomedical Sciences.
1992: Member of the Editorial Board, Бюллетень экспериментальной биологии и медицины (Bulletin of Experimental Biology and Medicine).
1991: Member of the Editorial Board, Клеточные технологии в биологии и медицине (Cell Technologies in Biology and Medicine).
1990: Deputy Editor-in-chief, Биотехнология.
Russian Researchers Assess the Power of T-Cell Immune Response to Omicron BA.1 and BA.2
Scholars from HSE University and the RAS Institute of Bioorganic Chemistry have demonstrated the efficiency of T-cell immune response against the Omicron variant of SARS-CoV-2. In approximately 90% of vaccinated Europeans, T-cell immunity was as effective against Omicron as with other variants. The results of the study were published in PeerJ.
Members of the International Laboratory of Microphysiological Systems and the Laboratory of Molecular Physiology participated in RECOMB 2021
25th International Conference on Research in Computational Molecular Biology (RECOMB 2021) was held online on August 29th - September 2nd. Staff of the Faculty of Biology and Biotechnology - Stepan Nersisyan, Alexey Galatenko, Diana Maltseva and Alexander Tonevitsky participated in a poster session with the report «miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence»
The International Laboratory of Microphysiological Systems at the 11th World Congress on Alternatives and Uses of Animals in Natural Sciences (WC11)
Alexander G. Tonevitsky, Leading Research Fellow of the International Laboratory of Microphysiological Systems, took part at the 11th World Congress on Alternatives and Use of Animals in Natural Sciences (WC11)
Russian Scientists Investigate the Immune Response to SARS-CoV-2 Variants
HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.
Hormones Can Help Brain Recover after Injury
An international team of researchers including Alexander Tonevitsky, Professor at HSE’s Faculty of Biology and Biotechnology, found that pituitary hormones may produce different effects on the left and right sides of the body following a traumatic brain injury. These differences can accelerate the development of motor disorders. Researchers are trying to determine whether treatment that blocks the corresponding hormones can counteract these effects. The results of the study were published in the journal eLife.
HSE Researchers Discover Nucleotide Sequence Responsible for Effectively Fighting Pathologies
Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors). The discovery will help predict errors in microRNA behaviour and create drugs that can detect targets (such as viruses) more effectively. The results of the study have been published in the RNA Biology journal.
HSE University and Business Russia to Establish Bioeconomy Advisory Board
The decision to establish the Advisory Board was made during a meeting between the Investment Club of Business Russia (‘Delovaya Rossiya’, an all-Russia public organization), and the HSE University Faculty of Biology and Biotechnology, which launched a new Master’s Programme in Bioeconomics last year. The Advisory Board will include leading researchers, entrepreneurs, and investors working in the fields of biotechnology, environmental studies, and sustainable development. Sergey Nedoroslev, Business Russia Co-Chair, and Alexander Tonevitsky, Dean of the Faculty of Biology and Biotechnology at HSE University, will also serve as board members.
Nikita Anisimov Appointed Acting Rector of HSE University
On July 2, Mr Anisimov was introduced to the HSE Academic Council at its meeting at HSE campus in Pokrovka. Valery Falkov, Minister of Science and Higher Education of the Russian Federation, Yaroslav Kuzminov, HSE University Academic Supervisor, and HSE University President Alexander Shokhin took part in the meeting.
Researchers Establish Intracellular Interaction Network in Breast Cancer
HSE University researchers have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE.
Researchers Reveal Genetic Predisposition to Severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.
Members of the International Laboratory of Microphysiological Systems and students of the Faculty of Biology and Biotechnology gave an interview to the correspondent of “MIR” TV company on the results of their study of molecules capable to suppress the replication of coronaviruses
Faculty of Biology and Biotechnology researchers in their interview to the correspondent of «MIR» TV company talked about their study on interactions between microRNA molecules and human coronaviruses.
Researchers Find Therapeutic Targets to Fight SARS-CoV-2
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.
Joint Seminar of HSE Faculty of Biology and Biotechnology and George Mason University
This June, first-year undergraduate students of the HSE Faculty of Biology and Biotechnology took part in an online seminar at George Mason University (USA). The seminar was part of the Coronavirus Research Update summer course, taught by Professor Ancha Baranova.
HSE and RAS Institutes to Produce Future Generations of Scientists
On February 12 at the Russian Ministry of Education and Science, HSE and five institutes of the Russian Academy of Sciences (RAS) signed agreements to collaborate in the field of scientific education. The institutions have pledged to contribute to the development of new faculties of chemistry as well as biology and biotechnology at HSE.
‘HSE Is in a Class by Itself.’ Annual HSE International Advisory Committee Meeting Commences
New faculties, personnel development, internationalisation, and much more – these are all things on the agenda of the annual International Advisory Committee (IAC) meeting currently taking place in Moscow.
Alexander Tonevitsky Recognized as Distinguished Scientist of Russia
Alexander Tonevitsky, Dean of the HSE Faculty of Biology and Biotechnologies and corresponding member of the RAS, was awarded the honorary title of Distinguished Scientist of the Russian Federation. The awards ceremony was held in the Kremlin on November 27.
HSE Opens Two New Faculties
In 2019, HSE will begin enrolling students in undergraduate programmes at two new faculties: the Faculty of Chemistry, and the Faculty of Biology and Biotechnology. These faculties will work in partnership with leading RAS institutions where students will be carrying out research.